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The potential role of epigenetic modifications in the heritability of multiple sclerosis

Citation

Zhou, Y and Simpson Jr, S and Holloway, AF and Charlesworth, J and van der Mei, I and Taylor, BV, The potential role of epigenetic modifications in the heritability of multiple sclerosis, Multiple Sclerosis Journal, 20, (2) pp. 135-140. ISSN 1352-4585 (2014) [Refereed Article]

Copyright Statement

Copyright The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav

DOI: doi:10.1177/1352458514520911

Abstract

It is now well established that both genetic and environmental factors contribute to and interact in the development of multiple sclerosis (MS). However, the currently described causal genetic variants do not explain the majority of the heritability of MS, resulting in 'missing heritability'. Epigenetic mechanisms, which principally include DNA methylation, histone modifications and microRNA-mediated post-transcriptional gene silencing, may contribute a significant component of this missing heritability. As the development of MS is a dynamic process potentially starting with inflammation, then demyelination, remyelination and neurodegeneration, we have reviewed the dynamic epigenetic changes in these aspects of MS pathogenesis and describe how environmental risk factors may interact with epigenetic changes to manifest in disease.

Item Details

Item Type:Refereed Article
Keywords:Multiple sclerosis, epigenetics, DNA methylation, histone modification, microRNA
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Central Nervous System
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Nervous System and Disorders
Author:Zhou, Y (Mr Yuan Zhou)
Author:Simpson Jr, S (Dr Steve Simpson JR)
Author:Holloway, AF (Dr Adele Holloway)
Author:Charlesworth, J (Dr Jac Charlesworth)
Author:van der Mei, I (Associate Professor Ingrid van der Mei)
Author:Taylor, BV (Professor Bruce Taylor)
ID Code:90656
Year Published:2014
Web of Science® Times Cited:15
Deposited By:Menzies Institute for Medical Research
Deposited On:2014-04-15
Last Modified:2017-11-06
Downloads:0

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