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The potential role of epigenetic modifications in the heritability of multiple sclerosis
journal contribution
posted on 2023-05-17, 23:49 authored by Yuan ZhouYuan Zhou, Steve Simpson JRSteve Simpson JR, Adele HollowayAdele Holloway, Jac CharlesworthJac Charlesworth, Ingrid van der MeiIngrid van der Mei, Bruce TaylorBruce TaylorIt is now well established that both genetic and environmental factors contribute to and interact in the development of multiple sclerosis (MS). However, the currently described causal genetic variants do not explain the majority of the heritability of MS, resulting in 'missing heritability'. Epigenetic mechanisms, which principally include DNA methylation, histone modifications and microRNA-mediated post-transcriptional gene silencing, may contribute a significant component of this missing heritability. As the development of MS is a dynamic process potentially starting with inflammation, then demyelination, remyelination and neurodegeneration, we have reviewed the dynamic epigenetic changes in these aspects of MS pathogenesis and describe how environmental risk factors may interact with epigenetic changes to manifest in disease.
History
Publication title
Multiple Sclerosis JournalVolume
20Pagination
135-140ISSN
1352-4585Department/School
Menzies Institute for Medical ResearchPublisher
ArnoldPlace of publication
Hodder Headline Plc, 338 Euston Road, London, England, Nw1 3BhRights statement
Copyright The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.navRepository Status
- Restricted