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The potential role of epigenetic modifications in the heritability of multiple sclerosis
Citation
Zhou, Y and Simpson Jr, S and Holloway, AF and Charlesworth, J and van der Mei, I and Taylor, BV, The potential role of epigenetic modifications in the heritability of multiple sclerosis, Multiple Sclerosis Journal, 20, (2) pp. 135-140. ISSN 1352-4585 (2014) [Refereed Article]
Copyright Statement
Copyright The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav
DOI: doi:10.1177/1352458514520911
Abstract
It is now well established that both genetic and environmental factors contribute to and interact in the development of multiple sclerosis (MS). However, the currently described causal genetic variants do not explain the majority of the heritability of MS, resulting in 'missing heritability'. Epigenetic mechanisms, which principally include DNA methylation, histone modifications and microRNA-mediated post-transcriptional gene silencing, may contribute a significant component of this missing heritability. As the development of MS is a dynamic process potentially starting with inflammation, then demyelination, remyelination and neurodegeneration, we have reviewed the dynamic epigenetic changes in these aspects of MS pathogenesis and describe how environmental risk factors may interact with epigenetic changes to manifest in disease.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | Multiple sclerosis, epigenetics, DNA methylation, histone modification, microRNA |
| Research Division: | Medical and Health Sciences |
| Research Group: | Neurosciences |
| Research Field: | Central Nervous System |
| Objective Division: | Health |
| Objective Group: | Clinical Health (Organs, Diseases and Abnormal Conditions) |
| Objective Field: | Nervous System and Disorders |
| Author: | Zhou, Y (Mr Yuan Zhou) |
| Author: | Simpson Jr, S (Dr Steve Simpson JR) |
| Author: | Holloway, AF (Associate Professor Adele Holloway) |
| Author: | Charlesworth, J (Dr Jac Charlesworth) |
| Author: | van der Mei, I (Associate Professor Ingrid van der Mei) |
| Author: | Taylor, BV (Professor Bruce Taylor) |
| ID Code: | 90656 |
| Year Published: | 2014 |
| Web of Science® Times Cited: | 19 |
| Deposited By: | Menzies Institute for Medical Research |
| Deposited On: | 2014-04-15 |
| Last Modified: | 2017-11-06 |
| Downloads: | 0 |
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