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The potential role of epigenetic modifications in the heritability of multiple sclerosis


Zhou, Y and Simpson Jr, S and Holloway, AF and Charlesworth, J and van der Mei, I and Taylor, BV, The potential role of epigenetic modifications in the heritability of multiple sclerosis, Multiple Sclerosis Journal, 20, (2) pp. 135-140. ISSN 1352-4585 (2014) [Refereed Article]

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DOI: doi:10.1177/1352458514520911


It is now well established that both genetic and environmental factors contribute to and interact in the development of multiple sclerosis (MS). However, the currently described causal genetic variants do not explain the majority of the heritability of MS, resulting in 'missing heritability'. Epigenetic mechanisms, which principally include DNA methylation, histone modifications and microRNA-mediated post-transcriptional gene silencing, may contribute a significant component of this missing heritability. As the development of MS is a dynamic process potentially starting with inflammation, then demyelination, remyelination and neurodegeneration, we have reviewed the dynamic epigenetic changes in these aspects of MS pathogenesis and describe how environmental risk factors may interact with epigenetic changes to manifest in disease.

Item Details

Item Type:Refereed Article
Keywords:Multiple sclerosis, epigenetics, DNA methylation, histone modification, microRNA
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Central nervous system
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Zhou, Y (Mr Yuan Zhou)
UTAS Author:Simpson Jr, S (Dr Steve Simpson JR)
UTAS Author:Holloway, AF (Professor Adele Holloway)
UTAS Author:Charlesworth, J (Dr Jac Charlesworth)
UTAS Author:van der Mei, I (Professor Ingrid van der Mei)
UTAS Author:Taylor, BV (Professor Bruce Taylor)
ID Code:90656
Year Published:2014
Web of Science® Times Cited:23
Deposited By:Menzies Institute for Medical Research
Deposited On:2014-04-15
Last Modified:2017-11-06

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