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Relationship between DDAH gene variants and serum ADMA level in individuals with type 1 diabetes


Fogarty, RD and Abhary, S and Javadiyan, S and Kasmeridis, N and Petrovsky, N and Whiting, MJ and Craig, JE and Burdon, KP, Relationship between DDAH gene variants and serum ADMA level in individuals with type 1 diabetes, Journal of Diabetes and Its Complications, 26, (3) pp. 195-198. ISSN 1056-8727 (2012) [Refereed Article]

DOI: doi:10.1016/j.jdiacomp.2012.03.022


Asymmetric dimethylarginine (ADMA) levels are elevated in diabetes and likely contribute to diabetic complications such as retinopathy and nephropathy. The DDAH enzymes are primarily responsible for ADMA metabolism. Polymorphisms in the dimethylarginine dimethylaminohydrolase (DDAH) 1 and 2 genes have been previously associated with serum ADMA levels in type 2 diabetes (T2DM). We sought to determine whether they are also associated with ADMA levels in individuals with type 1 diabetes (T1DM). Serum ADMA concentrations were measured in 196 individuals with T1DM. Twenty-six tag SNPs in the DDAH1 gene and 10 in the DDAH2 gene were genotyped. One SNP in the DDAH1 gene (rs3738111) and one in the DDAH2 gene (rs805293) showed a correlation with serum ADMA levels; however, neither survived correction for multiple testing. We found limited evidence that genetic polymorphisms in DDAH genes influence serum ADMA levels in individuals with T1DM. This differs to findings in T2DM and may be due to underlying differences in the cohorts or to fundamental differences in the pathogenesis of the two types of diabetes.

Item Details

Item Type:Refereed Article
Keywords:ADMA; DDAH1; DDAH2; Diabetes
Research Division:Biological Sciences
Research Group:Genetics
Research Field:Gene mapping
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Burdon, KP (Professor Kathryn Burdon)
ID Code:90627
Year Published:2012
Web of Science® Times Cited:11
Deposited By:Menzies Institute for Medical Research
Deposited On:2014-04-15
Last Modified:2014-04-15

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