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The role of macrophages in allograft rejection
Citation
Wyburn, KR and Jose, MD and Wu, H and Atkins, RC and Chadban, SJ, The role of macrophages in allograft rejection, Transplantation, 80, (12) pp. 1641-7. ISSN 0041-1337 (2005) [Refereed Article]
Copyright Statement
Copyright 2005 Lippincott Williams & Wilkins
DOI: doi:10.1097/01.tp.0000173903.26886.20
Abstract
Macrophage accumulation has long been recognized as a feature of allograft rejection, yet the role of macrophages in rejection remains underappreciated. Macrophages contribute to both the innate and acquired arms of the alloimmune response and thus may be involved in all aspects of acute and chronic allograft rejection. Recent advances in macrophage biology have allowed a better understanding of the mechanisms of macrophage accumulation, their state of activation and the pleuripotent roles they play in allograft rejection. Therapeutic attention to macrophages, in addition to T lymphocytes, may lead to improved outcomes in organ transplantation.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | allograft rejection |
| Research Division: | Biomedical and Clinical Sciences |
| Research Group: | Clinical sciences |
| Research Field: | Nephrology and urology |
| Objective Division: | Health |
| Objective Group: | Clinical health |
| Objective Field: | Clinical health not elsewhere classified |
| UTAS Author: | Jose, MD (Professor Matthew Jose) |
| ID Code: | 90577 |
| Year Published: | 2005 |
| Web of Science® Times Cited: | 115 |
| Deposited By: | Medicine |
| Deposited On: | 2014-04-10 |
| Last Modified: | 2016-12-15 |
| Downloads: | 0 |
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