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The role of macrophages in allograft rejection
journal contribution
posted on 2023-05-17, 23:46 authored by Wyburn, KR, Matthew JoseMatthew Jose, Wu, H, Atkins, RC, Chadban, SJMacrophage accumulation has long been recognized as a feature of allograft rejection, yet the role of macrophages in rejection remains underappreciated. Macrophages contribute to both the innate and acquired arms of the alloimmune response and thus may be involved in all aspects of acute and chronic allograft rejection. Recent advances in macrophage biology have allowed a better understanding of the mechanisms of macrophage accumulation, their state of activation and the pleuripotent roles they play in allograft rejection. Therapeutic attention to macrophages, in addition to T lymphocytes, may lead to improved outcomes in organ transplantation.
History
Publication title
TransplantationVolume
80Issue
12Pagination
1641-7ISSN
0041-1337Department/School
Tasmanian School of MedicinePublisher
Lippincott Williams & WilkinsPlace of publication
530 Walnut St, Philadelphia, USA, Pa, 19106-3621Rights statement
Copyright 2005 Lippincott Williams & WilkinsRepository Status
- Restricted