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The role of macrophages in allograft rejection

Citation

Wyburn, KR and Jose, MD and Wu, H and Atkins, RC and Chadban, SJ, The role of macrophages in allograft rejection, Transplantation, 80, (12) pp. 1641-7. ISSN 0041-1337 (2005) [Refereed Article]

Copyright Statement

Copyright 2005 Lippincott Williams & Wilkins

DOI: doi:10.1097/01.tp.0000173903.26886.20

Abstract

Macrophage accumulation has long been recognized as a feature of allograft rejection, yet the role of macrophages in rejection remains underappreciated. Macrophages contribute to both the innate and acquired arms of the alloimmune response and thus may be involved in all aspects of acute and chronic allograft rejection. Recent advances in macrophage biology have allowed a better understanding of the mechanisms of macrophage accumulation, their state of activation and the pleuripotent roles they play in allograft rejection. Therapeutic attention to macrophages, in addition to T lymphocytes, may lead to improved outcomes in organ transplantation.

Item Details

Item Type:Refereed Article
Keywords:allograft rejection
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Nephrology and Urology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Urogenital System and Disorders
Author:Jose, MD (Professor Matthew Jose)
ID Code:90577
Year Published:2005
Web of Science® Times Cited:82
Deposited By:Medicine (Discipline)
Deposited On:2014-04-10
Last Modified:2016-12-15
Downloads:0

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