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Serum levels of macrophage-colony stimulating factor (M-CSF): a marker of kidney allograft rejection

journal contribution
posted on 2023-05-17, 23:45 authored by Le Meur, YL, Leprivey-Lorgeot, V, Mons, S, Matthew JoseMatthew Jose, Dantal, J, Lemauff, B, Aldigier, JC, Leroux-Robert, C, Praloran, V

BACKGROUND: Macrophage-colony stimulating factor (M-CSF) is the principal factor for survival of monocytes and macrophages that play an important role in allograft rejection. We studied M-CSF serum levels during successful renal transplantation and acute graft rejection.

METHODS: A total of 114 kidney allograft recipients were assessed for M-CSF levels by enzyme-linked immunosorbent assay (ELISA).

RESULTS: M-CSF serum levels were elevated in pre-transplant haemodialysis patients (611+/-355 IU/ml vs 168+/-61 in normal controls, P<0.01). Following successful renal transplantation, M-CSF decreased in the first month, stabilizing at 257+/-222 IU/ml (not significantly different from normal controls) in 52 post-transplant stable patients. There was no correlation between M-CSF level and creatinine clearance. M-CSF levels increased significantly (2-5 times) during biopsy-proven acute rejection episodes in 20 of 25 patients. All rejection episodes were successfully treated and serum M-CSF decreased rapidly to pre-rejection levels in 17/20 patients. In contrast, in five patients with cyclosporin toxicity and four patients with other causes of allograft dysfunction, M-CSF serum levels did not change.

CONCLUSIONS: M-CSF serum level might be a specific marker of acute rejection. The source of increased production during rejection warrants further investigation, with infiltrating T cells and resident kidney cells being likely candidates.

History

Publication title

Nephrology, Dialysis and Transplantation

Volume

19

Issue

7

Pagination

1862-5

ISSN

0931-0509

Department/School

Tasmanian School of Medicine

Publisher

Oxford Univ Press

Place of publication

Great Clarendon St, Oxford, England, Ox2 6Dp

Rights statement

Copyright 2004 ERA-EDTA

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

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