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Computer optimization of background electrolyte composition in the separation of metal ions by capillary electrophoresis
Citation
Billiet, HAH and Andersson, PE and Haddad, PR, Computer optimization of background electrolyte composition in the separation of metal ions by capillary electrophoresis, Electrophoresis, 17, (8) pp. 1367-1372. ISSN 0173-0835 (1996) [Refereed Article]
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Copyright Statement
The definitive published version is available online at: http://interscience.wiley.com
Official URL: http://interscience.wiley.com
DOI: doi:10.1002/elps.1150170815
Abstract
The iterative regression design developed earlier for high performance liquid chromatography (HPLC) has been applied successfully to the optimization of the separation of 11 metal ions by capillary electrophoresis. The parameters used for optimization were pH (over the range 3.5-5.0) and the concentration of 2-hydroxyisobutyric acid (HIBA) (2-20 mM) used as the complex-forming ligand added to the background electrolyte. Five initial experiments were performed and the response surface was calculated using the relative resolution product as criterion. Three additional experiments were sufficient to establish a stable optimum, with which all 11 metal ions were separated and well spread in the electropherogram. The total analysis time was less than 5 min.
Item Details
Item Type: | Refereed Article |
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Keywords: | Capillary electrophoresis • Metal ions • Iterative regression optimization • 2-Hydroxyisobutyric acid • Metal ligand complexes |
Research Division: | Chemical Sciences |
Research Group: | Analytical chemistry |
Research Field: | Instrumental methods (excl. immunological and bioassay methods) |
Objective Division: | Expanding Knowledge |
Objective Group: | Expanding knowledge |
Objective Field: | Expanding knowledge in the chemical sciences |
UTAS Author: | Andersson, PE (Dr Andersson) |
UTAS Author: | Haddad, PR (Professor Paul Haddad) |
ID Code: | 9009 |
Year Published: | 1996 |
Web of Science® Times Cited: | 9 |
Deposited By: | Chemistry |
Deposited On: | 1996-08-01 |
Last Modified: | 2010-03-10 |
Downloads: | 0 |
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