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Genetic study of diabetic retinopathy: Recruitment methodology and analysis of baseline characteristics
Citation
Kaidonis, G and Abhary, S and Daniell, M and Gillies, M and Fogarty, R and Petrovsky, N and Jenkins, A and Essex, R and Chang, JH and Pal, B and Hewitt, AW and Burdon, KP and Craig, JE, Genetic study of diabetic retinopathy: Recruitment methodology and analysis of baseline characteristics, Clinical and Experimental Ophthalmology, 42, (5) pp. 486-493. ISSN 1442-6404 (2014) [Refereed Article]
Copyright Statement
Copyright 2013 Royal Australian and New Zealand College of Ophthalmologists
Abstract
Methods: One thousand six hundred sixty-nine participants with either type 1 (T1) or type 2 (T2) diabetes mellitus (DM) aged 18 to 95 years were recruited in Australian hospital clinics. Individuals with T2DM had disease duration of at least 5 years and were taking oral hypoglycaemic medication, and/or insulin therapy. Participants underwent ophthalmic examination. Medical history and biochemistry results were collected. Venous blood was obtained for genetic analysis.
Results: Six hundred eighty-three diabetic cases (178 T1DM and 505 T2DM participants) with sight-threatening DR, defined as severe non-proliferative DR, proliferative DR or diabetic macular oedema were included in this analysis. Eight hundred twelve individuals with DM but no DR or minimal non-proliferative DR were recruited as controls (191 with T1DM and 621 with T2DM). The presence of sight-threatening DR was significantly correlated with DM duration, hypertension, nephropathy, neuropathy, HbA1C and body mass index. Diabetic macular oedema was associated with T2DM (P < 0.001), whereas proliferative DR was associated with T1DM (P < 0.001).
Conclusions: Adoption of a case-control study design involving extremes of the DR phenotype makes this a suitable cohort, for a well-powered genome-wide association study to detect genetic risk variants for DR.
Item Details
Item Type: | Refereed Article |
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Keywords: | diabetic macular oedema, diabetic retinopathy, genome-wide association study |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Ophthalmology and optometry |
Research Field: | Ophthalmology |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Hewitt, AW (Professor Alex Hewitt) |
UTAS Author: | Burdon, KP (Professor Kathryn Burdon) |
ID Code: | 90062 |
Year Published: | 2014 |
Web of Science® Times Cited: | 9 |
Deposited By: | Menzies Institute for Medical Research |
Deposited On: | 2014-03-26 |
Last Modified: | 2017-11-06 |
Downloads: | 0 |
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