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The Familial Tasmanian Haematological Malignancies Study (FaTHMS): its origins, its history and the phenomenon of anticipation
Citation
Lowenthal, RM and Tegg, EM and Dickinson, JL, The Familial Tasmanian Haematological Malignancies Study (FaTHMS): its origins, its history and the phenomenon of anticipation, Transfusion and Apheresis Science, 49, (2) pp. 113-115. ISSN 1473-0502 (2013) [Contribution to Refereed Journal]
DOI: doi:10.1016/j.transci.2013.07.011
Abstract
We began epidemiological studies of haematological malignancies (lymphomas, leukaemias and related diseases) in Tasmania, the island state of Australia, in 1972. Our work has identified a number of families each containing several cases. In contrast to reports from elsewhere, we recognised familial cases incorporating the range of haematological malignancies, that is, not confined to a single diagnosis. Furthermore the average number of cases per extended family tree has exceeded that of any prior report. An unexpected discovery from the detailed familial analysis was that of anticipation, the phenomenon whereby the symptoms of a disorder become apparent at an earlier age as it is passed on to the next generation. These findings strengthen the case for there being genetic anomalies underlying the development of haematological malignancies at least in some cases, and are the subject of ongoing research
Item Details
Item Type: | Contribution to Refereed Journal |
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Research Division: | Biomedical and Clinical Sciences |
Research Group: | Cardiovascular medicine and haematology |
Research Field: | Haematology |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Lowenthal, RM (Professor Ray Lowenthal) |
UTAS Author: | Tegg, EM (Dr Elizabeth Tegg) |
UTAS Author: | Dickinson, JL (Professor Joanne Dickinson) |
ID Code: | 89976 |
Year Published: | 2013 |
Web of Science® Times Cited: | 3 |
Deposited By: | Menzies Institute for Medical Research |
Deposited On: | 2014-03-20 |
Last Modified: | 2014-03-20 |
Downloads: | 0 |
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