File(s) under permanent embargo
Choroid plexus implants rescue Alzheimer's disease-like pathologies by modulating amyloid-β degradation
journal contribution
posted on 2023-05-17, 23:22 authored by Bolos, M, Antequera, D, Aldudo, J, Kristen, H, Bullido, MJ, Carro, EThe choroid plexuses (CP) release numerous biologically active enzymes and neurotrophic factors, and contain a subpopulation of neural progenitor cells providing the capacity to proliferate and differentiate into other types of cells. These characteristics make CP epithelial cells (CPECs) excellent candidates for cell therapy aiming at restoring brain tissue in neurodegenerative illnesses, including Alzheimer's disease (AD). In the present study, using in vitro approaches, we demonstrated that CP were able to diminish amyloid-β (Aβ) levels in cell cultures, reducing Aβ-induced neurotoxicity. For in vivo studies, CPECs were transplanted into the brain of the APP/PS1 murine model of AD that exhibits advanced Aβ accumulation and memory impairment. Brain examination after cell implantation revealed a significant reduction in brain Aβ deposits, hyperphosphorylation of tau, and astrocytic reactivity. Remarkably, the transplantation of CPECs was accompanied by a total behavioral recovery in APP/PS1 mice, improving spatial and non-spatial memory. These findings reinforce the neuroprotective potential of CPECs and the use of cell therapies as useful tools in AD.
History
Publication title
Cellular and Molecular Life SciencesVolume
71Issue
15Pagination
2947-2955ISSN
1420-682XDepartment/School
Menzies Institute for Medical ResearchPublisher
Birkhauser Verlag AgPlace of publication
Viadukstrasse 40-44, Po Box 133, Basel, Switzerland, Ch-4010Rights statement
Copyright 2013 Springer BaselRepository Status
- Restricted