eCite Digital Repository

Choroid plexus implants rescue Alzheimer's disease-like pathologies by modulating amyloid-β degradation

Citation

Bolos, M and Antequera, D and Aldudo, J and Kristen, H and Bullido, MJ and Carro, E, Choroid plexus implants rescue Alzheimer's disease-like pathologies by modulating amyloid-β degradation, Cellular and Molecular Life Sciences, 71, (15) pp. 2947-2955. ISSN 1420-682X (2013) [Refereed Article]

Copyright Statement

Copyright 2013 Springer Basel

DOI: doi:10.1007/s00018-013-1529-4

Abstract

The choroid plexuses (CP) release numerous biologically active enzymes and neurotrophic factors, and contain a subpopulation of neural progenitor cells providing the capacity to proliferate and differentiate into other types of cells. These characteristics make CP epithelial cells (CPECs) excellent candidates for cell therapy aiming at restoring brain tissue in neurodegenerative illnesses, including Alzheimer's disease (AD). In the present study, using in vitro approaches, we demonstrated that CP were able to diminish amyloid-β (Aβ) levels in cell cultures, reducing Aβ-induced neurotoxicity. For in vivo studies, CPECs were transplanted into the brain of the APP/PS1 murine model of AD that exhibits advanced Aβ accumulation and memory impairment. Brain examination after cell implantation revealed a significant reduction in brain Aβ deposits, hyperphosphorylation of tau, and astrocytic reactivity. Remarkably, the transplantation of CPECs was accompanied by a total behavioral recovery in APP/PS1 mice, improving spatial and non-spatial memory. These findings reinforce the neuroprotective potential of CPECs and the use of cell therapies as useful tools in AD.

Item Details

Item Type:Refereed Article
Keywords:Choroid plexus, Alzheimer’s disease, Transgenic mice, Cell implants, Amyloidosis, Memory
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Cellular Nervous System
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Biological Sciences
Author:Bolos, M (Dr Marta Bolos Jurado)
ID Code:89970
Year Published:2013
Web of Science® Times Cited:10
Deposited By:Menzies Institute for Medical Research
Deposited On:2014-03-20
Last Modified:2016-12-16
Downloads:0

Repository Staff Only: item control page