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Alzheimer's disease-like impaired cognition in endothelial-specific megalin-null mice


Dietrich, M and Antequera, D and Pascual, C and Castro, N and Bolos, M and Carro, E, Alzheimer's disease-like impaired cognition in endothelial-specific megalin-null mice, Journal of Alzheimer'S Disease, 39, (4) pp. 711-717. ISSN 1387-2877 (2014) [Refereed Article]

DOI: doi:10.3233/JAD-131604


Megalin has been suggested to be involved in Alzheimer's disease (AD), mediating blood-brain barrier (BBB) transport of multiple ligands, including amyloid-β peptide (Aβ), but also neuroprotective factors. Because no transgenic model is currently available to study this concept, we have obtained transgenic mice blocking megalin expression at the BBB. These endothelial megalin deficient (EMD) mice developed increased anxiety behavior and impaired learning ability and recognition memory, similar to symptoms described in AD. Degenerating neurons were also observed in the cerebral cortex of EMD mice. In view of our findings we suggest that, in mice, megalin deficiency at the BBB leads to neurodegeneration.

Item Details

Item Type:Refereed Article
Keywords:Alzheimer's disease, cognitive impairment, memory, neurodegeneration, transgenic mice
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Cellular nervous system
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the biological sciences
UTAS Author:Bolos, M (Dr Marta Bolos Jurado)
ID Code:89968
Year Published:2014
Web of Science® Times Cited:16
Deposited By:Menzies Institute for Medical Research
Deposited On:2014-03-20
Last Modified:2014-03-20

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