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The global burden of hip and knee osteoarthritis: Estimates from the Global Burden of Disease 2010 study

Citation

Cross, M and Smith, E and Hoy, D and Nolte, S and Ackerman, I and Fransen, M and Bridgett, L and Williams, S and Guillemin, F and Hill, CL and Laslett, LL and Jones, G and Cicuttini, F and Osborne, R and Vos, T and Buchbinder, R and Woolf, A and March, L, The global burden of hip and knee osteoarthritis: Estimates from the Global Burden of Disease 2010 study, Annals of the Rheumatic Diseases, 73, (7) pp. 1323-1330. ISSN 0003-4967 (2014) [Refereed Article]

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Copyright 2013 the authors

DOI: doi:10.1136/annrheumdis-2013-204763

Abstract

Objective: To estimate the global burden of hip and knee osteoarthritis (OA) as part of the Global Burden of Disease 2010 study and to explore how the burden of hip and knee OA compares with other conditions. Methods: Systematic reviews were conducted to source age-specific and sex-specific epidemiological data for hip and knee OA prevalence, incidence and mortality risk. The prevalence and incidence of symptomatic, radiographic and self-reported hip or knee OA were included. Three levels of severity were defined to derive disability weights (DWs) and severity distribution (proportion with mild, moderate and severe OA). The prevalence by country and region was multiplied by the severity distribution and the appropriate disability weight to calculate years of life lived with disability (YLDs). As there are no deaths directly attributed to OA, YLDs equate disability-adjusted life years (DALYs). Results: Globally, of the 291 conditions, hip and knee OA was ranked as the 11th highest contributor to global disability and 38th highest in DALYs. The global age-standardised prevalence of knee OA was 3.8% (95% uncertainty interval (UI) 3.6% to 4.1%) and hip OA was 0.85% (95% UI 0.74% to 1.02%), with no discernible change from 1990 to 2010. Prevalence was higher in females than males. YLDs for hip and knee OA increased from 10.5 million in 1990 (0.42% of total DALYs) to 17.1 million in 2010 (0.69% of total DALYs). Conclusions: Hip and knee OA is one of the leading causes of global disability. Methodological issues within this study make it highly likely that the real burden of OA has been underestimated. With the aging and increasing obesity of the world's population, health professions need to prepare for a large increase in the demand for health services to treat hip and knee OA. © 2014 BMJ Publishing Group Ltd & European League Against Rheumatism.

Item Details

Item Type:Refereed Article
Keywords:burden of disease; osteoarthritis; knee osteoarthritis; hip osteoarthritis; epidemiology; disability
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Rheumatology and Arthritis
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Skeletal System and Disorders (incl. Arthritis)
Author:Laslett, LL (Dr Laura Laslett)
Author:Jones, G (Professor Graeme Jones)
ID Code:89804
Year Published:2014
Web of Science® Times Cited:464
Deposited By:Menzies Institute for Medical Research
Deposited On:2014-03-15
Last Modified:2018-03-09
Downloads:3 View Download Statistics

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