eCite Digital Repository

The use of heterochromatic flicker photometry to determine macular pigment optical density in a healthy Australian population


Abell, RG and Hewitt, AW and Andric, M and Allen, PL and Verma, N, The use of heterochromatic flicker photometry to determine macular pigment optical density in a healthy Australian population, Graefe's Archive for Clinical and Experimental Ophthalmology, 252, (3) pp. 417-421. ISSN 1435-702X (2014) [Refereed Article]

Copyright Statement

Copyright 2014 Springer-Verlag Berlin Heidelberg

DOI: doi:10.1007/s00417-013-2554-6


Purpose: To establish the normal macular pigment density (MPOD) in a healthy adult Australian sample using heterochromatic flicker photometry (HFP).

Methods: Macular pigment density was measured using heterochromatic flicker photometry in a total of 201 subjects ranging in age from 21 to 84 years with healthy macula. Fifty-seven of the healthy subjects also completed a food-frequency dietary questionnaire. Best-corrected visual acuity (BCVA) was measured using logMAR, chart and macular morphological profiles were assessed using high-resolution integrated Fourier-domain optical coherence tomography (OCT).

Results: The average MPOD value was 0.41  0.20 (range 0.070.79). There was no statistically significant difference between values in the left and right eye, with good interocular agreement (0.41 vs 0.40, r  =  0.893, p  <  0.01). Age significantly predicted MPOD score (R2  =  0.07, p  <  0.05). A subgroup analysis of patients who completed the dietary questionnaire revealed a close correlation between higher diet scores and higher MPOD (r  =  0.720, p  =  0.031). There was no effect of smoking, gender, or iris colour on MPOD values. There was no significant correlation between BCVA, macular OCT profiles, and MPOD.

Conclusion: Given that MPOD values are potentially affected by geographical variation, we have determined a mean MPOD value for healthy subjects in a population south of the equator, providing a reference point for future studies on Caucasian samples.

Item Details

Item Type:Refereed Article
Keywords:macular pigment optical density, heterochromatic flicker photometry
Research Division:Biomedical and Clinical Sciences
Research Group:Ophthalmology and optometry
Research Field:Vision science
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Hewitt, AW (Professor Alex Hewitt)
UTAS Author:Allen, PL (Dr Penny Allen)
ID Code:89521
Year Published:2014
Web of Science® Times Cited:9
Deposited By:Rural Clinical School
Deposited On:2014-03-06
Last Modified:2017-11-07

Repository Staff Only: item control page