Abell, RG and Hewitt, AW and Andric, M and Allen, PL and Verma, N, The use of heterochromatic flicker photometry to determine macular pigment optical density in a healthy Australian population, Graefe's Archive for Clinical and Experimental Ophthalmology, 252, (3) pp. 417-421. ISSN 1435-702X (2014) [Refereed Article]
Copyright 2014 Springer-Verlag Berlin Heidelberg
Purpose: To establish the normal macular pigment density (MPOD) in a healthy adult Australian sample using heterochromatic flicker photometry (HFP).
Methods: Macular pigment density was measured using heterochromatic flicker photometry in a total of 201 subjects ranging in age from 21 to 84 years with healthy macula. Fifty-seven of the healthy subjects also completed a food-frequency dietary questionnaire. Best-corrected visual acuity (BCVA) was measured using logMAR, chart and macular morphological profiles were assessed using high-resolution integrated Fourier-domain optical coherence tomography (OCT).
Results: The average MPOD value was 0.41 ± 0.20 (range 0.07–0.79). There was no statistically significant difference between values in the left and right eye, with good interocular agreement (0.41 vs 0.40, r = 0.893, p < 0.01). Age significantly predicted MPOD score (R2 = 0.07, p < 0.05). A subgroup analysis of patients who completed the dietary questionnaire revealed a close correlation between higher diet scores and higher MPOD (r = 0.720, p = 0.031). There was no effect of smoking, gender, or iris colour on MPOD values. There was no significant correlation between BCVA, macular OCT profiles, and MPOD.
Conclusion: Given that MPOD values are potentially affected by geographical variation, we have determined a mean MPOD value for healthy subjects in a population south of the equator, providing a reference point for future studies on Caucasian samples.
|Item Type:||Refereed Article|
|Keywords:||macular pigment optical density, heterochromatic flicker photometry|
|Research Division:||Medical and Health Sciences|
|Research Group:||Ophthalmology and Optometry|
|Research Field:||Vision Science|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Hearing, Vision, Speech and Their Disorders|
|Author:||Hewitt, AW (Professor Alex Hewitt)|
|Author:||Allen, PL (Dr Penny Allen)|
|Web of Science® Times Cited:||3|
|Deposited By:||Rural Clinical School|
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