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Accelerated antigen sampling and transport by airway mucosal dendritic cells following inhalation of a bacterial stimulus

Citation

Jahnsen, FL and Strickland, DH and Thomas, JA and Tobagus, IT and Napoli, S and Zosky, GR and Turner, DJ and Sly, PD and Stumbles, PA and Holt, PG, Accelerated antigen sampling and transport by airway mucosal dendritic cells following inhalation of a bacterial stimulus, Journal of Immunology, 177, (9) pp. 5861-7. ISSN 0022-1767 (2006) [Refereed Article]

DOI: doi:10.4049/jimmunol.177.9.5861

Abstract

An increase in the tempo of local dendritic cell (DC)-mediated immune surveillance is a recognized feature of the response to acute inflammation at airway mucosal surfaces, and transient up-regulation of the APC functions of these DC preceding their emigration to regional lymph nodes has recently been identified as an important trigger for T cell-mediated airway tissue damage in diseases such as asthma. In this study, using a rat model, we demonstrate that the kinetics of the airway mucosal DC (AMDC) response to challenge with heat-killed bacteria is considerably more rapid and as a consequence more effectively compartmentalized than that in recall responses to soluble Ag. Notably, Ag-bearing AMDC expressing full APC activity reach regional lymph nodes within 30 min of cessation of microbial exposure, and in contrast to recall responses to nonpathogenic Ags, there is no evidence of local expression of APC activity within the airway mucosa preceding DC emigration. We additionally demonstrate that, analogous to that reported in the gut, a subset of airway intraepithelial DC extend their processes into the airway lumen. This function is constitutively expressed within the AMDC population, providing a mechanism for continuous immune surveillance of the airway luminal surface in the absence of "danger" signals.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Cardiorespiratory Medicine and Haematology
Research Field:Respiratory Diseases
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Respiratory System and Diseases (incl. Asthma)
UTAS Author:Zosky, GR (Professor Graeme Zosky)
ID Code:89489
Year Published:2006
Web of Science® Times Cited:119
Deposited By:Medicine
Deposited On:2014-03-05
Last Modified:2014-03-05
Downloads:0

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