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Lack of long-term effects of respiratory syncytial virus infection on airway function in mice


Collins, RA and Gualano, RC and Zosky, GR and Chiappetta, CL and Turner, DJ and Colasurdo, GN and Hantos, Z and Sly, PD, Lack of long-term effects of respiratory syncytial virus infection on airway function in mice, Respiration Physiology and Neurobiology, 156, (3) pp. 345-52. ISSN 1569-9048 (2007) [Refereed Article]

DOI: doi:10.1016/j.resp.2006.11.009


Epidemiological data suggests lower respiratory infections (LRI) with respiratory syncytial virus (RSV) are capable of causing long-term abnormalities in airway function. To directly test the effects of RSV LRI, we infected adult and weanling BALB/c mice with RSV (A2) or vehicle. Respiratory system impedance was used to assess baseline airway function and responses to iv methacholine (MCh) at 4, 8, 24 and 34 weeks post infection. In vitro airway responses were measured 24 weeks post infection using electrical field stimulation and MCh. Mice infected as adults showed no alterations in airway function. Mice infected as weanlings had increased MCh responses 24 weeks post infection. However, the increased response was not present 34 weeks post infection nor accompanied by alterations in in vitro responses or airway morphometry. This study did not detect long-lasting changes in airway function following RSV infection in mice. These data do not provide support for alterations in airway structure or function being responsible for the observed relationship between RSV infection in infants and asthma in later life.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Cardiovascular medicine and haematology
Research Field:Respiratory diseases
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Zosky, GR (Professor Graeme Zosky)
ID Code:89487
Year Published:2007
Web of Science® Times Cited:6
Deposited By:Medicine
Deposited On:2014-03-05
Last Modified:2014-03-05

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