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Absence of cholinergic airway tone in normal BALB/c mice


Larcombe, AN and Zosky, GR and Bozanich, EM and Turner, DJ and Hantos, Z and Sly, PD, Absence of cholinergic airway tone in normal BALB/c mice, Respiration Physiology and Neurobiology, 161, (3) pp. 223-9. ISSN 1569-9048 (2008) [Refereed Article]

DOI: doi:10.1016/j.resp.2008.01.009


Basal airway smooth muscle (ASM) tone has not been demonstrated in mice in vivo. To determine whether basal ASM tone is present in mouse airways we measured respiratory system impedance (Zrs) before and after either atropine or bilateral vagotomy. Zrs was measured using forced oscillations delivered via a wave-tube during slow ( approximately 35s) inflation-deflation maneuvers between transrespiratory pressures (Prs) of 0 and 20 cm H2O. A constant-phase tissue model was applied to the Zrs to calculate airway resistance (R aw), tissue damping (G) and elastance (H). Thoracic gas volume (TGV) was determined plethysmographically at Prs=0 cm H2O and by integration of the inspiratory flow. The relationship between conductance (G aw=1/R aw) and TGV during inflation was also examined. Neither atropine nor vagotomy produced any change in R aw, H, eta (=G/H), TGV or the slope of G aw vs. TGV that was different to that observed in the relevant control groups. These data show that BALB/c mice do not have cholinergic ASM tone in vivo.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Cardiovascular medicine and haematology
Research Field:Respiratory diseases
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Zosky, GR (Professor Graeme Zosky)
ID Code:89481
Year Published:2008
Web of Science® Times Cited:8
Deposited By:Medicine
Deposited On:2014-03-05
Last Modified:2014-03-05

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