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Lung volume recruitment maneuvers and respiratory system mechanics in mechanically ventilated mice


Cannizzaro, V and Berry, LJ and Nicholls, PK and Zosky, GR and Turner, DJ and Hantos, Z and Sly, PD, Lung volume recruitment maneuvers and respiratory system mechanics in mechanically ventilated mice, Respiration Physiology and Neurobiology, 169, (3) pp. 243-51. ISSN 1569-9048 (2009) [Refereed Article]

DOI: doi:10.1016/j.resp.2009.09.012


The study aim was to establish how recruitment maneuvers (RMs) influence lung mechanics and to determine whether RMs produce lung injury. Healthy BALB/c mice were allocated to receive positive end-expiratory pressure (PEEP) at 2 or 6 cmH(2)O and volume- (20 or 40 mL/kg) or pressure-controlled (25 cmH(2)O) RMs every 5 or 75 min for 150 min. The low-frequency forced oscillation technique was used to measure respiratory input impedance. Large RMs resulting in peak airway opening pressures (P(ao))>30 cmH(2)O did not increase inflammatory response or affect transcutaneous oxygen saturation but significantly lowered airway resistance, tissue damping and tissue elastance; the latter changes are likely associated with the bimodal pressure-volume behavior observed in mice. PEEP increase alone and application of RMs producing peak P(ao) below 25 cmH(2)O did not prevent or reverse changes in lung mechanics; whereas frequent application of substantial RMs on top of elevated PEEP levels produced stable lung mechanics without signs of lung injury.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Cardiovascular medicine and haematology
Research Field:Respiratory diseases
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Zosky, GR (Professor Graeme Zosky)
ID Code:89475
Year Published:2009
Web of Science® Times Cited:12
Deposited By:Medicine
Deposited On:2014-03-05
Last Modified:2014-03-05

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