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Lung volume recruitment maneuvers and respiratory system mechanics in mechanically ventilated mice
Citation
Cannizzaro, V and Berry, LJ and Nicholls, PK and Zosky, GR and Turner, DJ and Hantos, Z and Sly, PD, Lung volume recruitment maneuvers and respiratory system mechanics in mechanically ventilated mice, Respiration Physiology and Neurobiology, 169, (3) pp. 243-51. ISSN 1569-9048 (2009) [Refereed Article]
DOI: doi:10.1016/j.resp.2009.09.012
Abstract
The study aim was to establish how recruitment maneuvers (RMs) influence lung mechanics and to determine whether RMs produce lung injury. Healthy BALB/c mice were allocated to receive positive end-expiratory pressure (PEEP) at 2 or 6 cmH(2)O and volume- (20 or 40 mL/kg) or pressure-controlled (25 cmH(2)O) RMs every 5 or 75 min for 150 min. The low-frequency forced oscillation technique was used to measure respiratory input impedance. Large RMs resulting in peak airway opening pressures (P(ao))>30 cmH(2)O did not increase inflammatory response or affect transcutaneous oxygen saturation but significantly lowered airway resistance, tissue damping and tissue elastance; the latter changes are likely associated with the bimodal pressure-volume behavior observed in mice. PEEP increase alone and application of RMs producing peak P(ao) below 25 cmH(2)O did not prevent or reverse changes in lung mechanics; whereas frequent application of substantial RMs on top of elevated PEEP levels produced stable lung mechanics without signs of lung injury.
Item Details
Item Type: | Refereed Article |
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Research Division: | Medical and Health Sciences |
Research Group: | Cardiorespiratory Medicine and Haematology |
Research Field: | Respiratory Diseases |
Objective Division: | Health |
Objective Group: | Clinical Health (Organs, Diseases and Abnormal Conditions) |
Objective Field: | Respiratory System and Diseases (incl. Asthma) |
UTAS Author: | Zosky, GR (Professor Graeme Zosky) |
ID Code: | 89475 |
Year Published: | 2009 |
Web of Science® Times Cited: | 8 |
Deposited By: | Medicine |
Deposited On: | 2014-03-05 |
Last Modified: | 2014-03-05 |
Downloads: | 0 |
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