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In utero cigarette smoke exposure impairs somatic and lung growth in BALB/c mice
journal contribution
posted on 2023-05-17, 22:54 authored by Larcombe, AN, Foong, RE, Berry, LJ, Graeme ZoskyGraeme Zosky, Sly, PDThe aim of this study was to assess whether in utero tobacco smoke exposure alone affects early-life lung growth and development. Pregnant BALB/c mice were exposed to cigarette smoke from six cigarettes per day, or air, from day 8 to 20 of gestation. At 2 weeks of age, pups were weighed and had their lung volumes and lung mechanics measured. Pups born from mothers exposed to cigarette smoke (CS pups; n=17) were significantly lighter (6.76 ± 0.76 versus 7.72 ± 0.68 g) and had lower lung volumes (0.123 ± 0.02 versus 0.149 ± 0.02 mL) than control pups (n=20). Respiratory mechanics were adversely impacted by cigarette smoke exposure. CS pups had higher baseline airway resistance, tissue damping and tissue elastance. These differences were largely due to lower lung volumes. Both tissue damping and elastance were increased excessively in CS pups at high transrespiratory pressures, while other parameters were not affected. There were no histological differences between groups. In utero tobacco smoke exposure significantly affects growth and development in BALB/c mice. These impacts may partially explain the susceptibility of infants born to smoking mothers to early respiratory disease and chronic respiratory disease as adults.
History
Publication title
The European Respiratory JournalVolume
38Issue
4Pagination
932-938ISSN
0903-1936Department/School
Tasmanian School of MedicinePublisher
European Respiratory Soc Journals LtdPlace of publication
146 West St, Ste 2.4, Huttons Bldg, Sheffield, England, S1 4EsRepository Status
- Restricted