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Factors influencing the assessment of lung function in mice with influenza-induced lung disease


Larcombe, AN and Zosky, GR and Thamrin, C and Bozanich, EM and Hantos, Z and Sly, PD, Factors influencing the assessment of lung function in mice with influenza-induced lung disease, Influenza and Other Respiratory Viruses, 7, (6) pp. 889-894. ISSN 1750-2640 (2013) [Refereed Article]

DOI: doi:10.1111/irv.12034


BACKGROUND: The constant-phase model (CPM) is commonly fit to respiratory system input impedance (Zrs) to estimate lung mechanics. Driving signal frequencies and the method of model fitting may influence the results, especially in cases of severe lung disease or under severe bronchoconstriction. OBJECTIVE: To illustrate the effects of different CPM fits to Zrs data using a mouse model of influenza-induced lung disease. METHODS: BALB/c mice infected with influenza (or control) were challenged with methacholine. The CPM was fitted to Zrs, measured between 025 and 19625 Hz, using both unweighted and weighted fits. The effect of different lowest frequencies was assessed. RESULTS AND CONCLUSIONS: For influenza-infected mice, the unweighted fit was poor, and airway resistance (Raw) was often biologically impossible. The weighted fit provided more realistic estimates of Raw. Different model fits and minimal frequencies had little effect on tissue mechanics.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Cardiovascular medicine and haematology
Research Field:Respiratory diseases
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Zosky, GR (Professor Graeme Zosky)
ID Code:89457
Year Published:2013
Web of Science® Times Cited:3
Deposited By:Medicine
Deposited On:2014-03-05
Last Modified:2017-10-06

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