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Early life arsenic exposure and acute and long-term responses to influenza A infection in mice

journal contribution
posted on 2023-05-17, 22:52 authored by Ramsey, KA, Foong, RE, Sly, PD, Larcombe, AN, Graeme ZoskyGraeme Zosky
BACKGROUND: Arsenic is a significant global environmental health problem. Exposure to arsenic in early life has been shown to increase the rate of respiratory infections during infancy, reduce childhood lung function, and increase the rates of bronchiectasis in early adulthood. OBJECTIVE: We aimed to determine if early life exposure to arsenic exacerbates the response to early life influenza infection in mice. METHODS: C57BL/6 mice were exposed to arsenic in utero and throughout postnatal life. At 1 week of age, a subgroup of mice were infected with influenza A. We then assessed the acute and long-term effects of arsenic exposure on viral clearance, inflammation, lung structure, and lung function. RESULTS: Early life arsenic exposure reduced the clearance of and exacerbated the inflammatory response to influenza A, and resulted in acute and long-term changes in lung mechanics and airway structure. CONCLUSIONS: Increased susceptibility to respiratory infections combined with exaggerated inflammatory responses throughout early life may contribute to the development of bronchiectasis in arsenic-exposed populations.

History

Publication title

Environmental Health Perspectives

Volume

121

Issue

10

Pagination

1187-93

ISSN

0091-6765

Department/School

Tasmanian School of Medicine

Publisher

Us Dept Health Human Sciences Public Health Science

Place of publication

Natl Inst Health, Natl Inst Environmental Health Sciences, Po Box 12233, Res Triangle Pk, USA, Nc, 27709-2233

Repository Status

  • Restricted

Socio-economic Objectives

Public health (excl. specific population health) not elsewhere classified

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