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Variability and consistency in lung inflammatory responses to particles with a geogenic origin


Zosky, GR and Boylen, CE and Wong, RS and Smirk, MN and Gutierrez, L and Shan Siaw, W and Devine, B and Maley, F and Cook, A, Variability and consistency in lung inflammatory responses to particles with a geogenic origin, Respirology, 19, (1) pp. 58-66. ISSN 1323-7799 (2014) [Refereed Article]

Copyright Statement

Copyright 2013 The Authors;Copyright 2013 Asian Pacific Society of Respirology

DOI: doi:10.1111/resp.12150


BACKGROUND AND OBJECTIVE: Particulate matter <10 μm (PM10 ) is well recognized as being an important driver of respiratory health; however, the impact of PM10 of geogenic origin on inflammatory responses in the lung is poorly understood. This study aimed to assess the lung inflammatory response to community sampled geogenic PM10 . METHODS: This was achieved by collecting earth material from two regional communities in Western Australia (Kalgoorlie-Boulder and Newman), extracting the PM10 fraction and exposing mice by intranasal instillation to these particles. The physicochemical characteristics of the particles were assessed and lung inflammatory responses were compared to control particles. The primary outcomes were cellular influx and cytokine production in the lungs of the exposed mice. RESULTS: The physical and chemical characteristics of the PM10 from Kalgoorlie and Newman differed with the latter having a higher concentration of Fe and a larger median diameter. Control particles (2.5 μm polystyrene) caused a significant influx of inflammatory cells (neutrophils) with little production of proinflammatory cytokines. In contrast, the geogenic particles induced the production of MIP-2, IL-6 and a significant influx of neutrophils. Qualitatively, the response following exposure to particles from Kalgoorlie and Newman were consistent; however, the magnitude of the response was substantially higher in the mice exposed to particles from Newman. CONCLUSIONS: The unique physicochemical characteristics of geogenic particles induced a proinflammatory response in the lung. These data suggest that particle composition should be considered when setting community standards for PM exposure, particularly in areas exposed to high geogenic particulate loads.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Cardiovascular medicine and haematology
Research Field:Respiratory diseases
Objective Division:Health
Objective Group:Public health (excl. specific population health)
Objective Field:Public health (excl. specific population health) not elsewhere classified
UTAS Author:Zosky, GR (Professor Graeme Zosky)
ID Code:89441
Year Published:2014
Web of Science® Times Cited:27
Deposited By:Medicine
Deposited On:2014-03-05
Last Modified:2017-11-06

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