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Variability and consistency in lung inflammatory responses to particles with a geogenic origin
Citation
Zosky, GR and Boylen, CE and Wong, RS and Smirk, MN and Gutierrez, L and Shan Siaw, W and Devine, B and Maley, F and Cook, A, Variability and consistency in lung inflammatory responses to particles with a geogenic origin, Respirology, 19, (1) pp. 58-66. ISSN 1323-7799 (2014) [Refereed Article]
Copyright Statement
Copyright 2013 The Authors;Copyright 2013 Asian Pacific Society of Respirology
Abstract
BACKGROUND AND OBJECTIVE:
Particulate matter <10 μm (PM10 ) is well recognized as being an important driver of respiratory health; however, the impact of PM10 of geogenic origin on inflammatory responses in the lung is poorly understood. This study aimed to assess the lung inflammatory response to community sampled geogenic PM10 .
METHODS:
This was achieved by collecting earth material from two regional communities in Western Australia (Kalgoorlie-Boulder and Newman), extracting the PM10 fraction and exposing mice by intranasal instillation to these particles. The physicochemical characteristics of the particles were assessed and lung inflammatory responses were compared to control particles. The primary outcomes were cellular influx and cytokine production in the lungs of the exposed mice.
RESULTS:
The physical and chemical characteristics of the PM10 from Kalgoorlie and Newman differed with the latter having a higher concentration of Fe and a larger median diameter. Control particles (2.5 μm polystyrene) caused a significant influx of inflammatory cells (neutrophils) with little production of proinflammatory cytokines. In contrast, the geogenic particles induced the production of MIP-2, IL-6 and a significant influx of neutrophils. Qualitatively, the response following exposure to particles from Kalgoorlie and Newman were consistent; however, the magnitude of the response was substantially higher in the mice exposed to particles from Newman.
CONCLUSIONS:
The unique physicochemical characteristics of geogenic particles induced a proinflammatory response in the lung. These data suggest that particle composition should be considered when setting community standards for PM exposure, particularly in areas exposed to high geogenic particulate loads.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Research Division: | Biomedical and Clinical Sciences |
| Research Group: | Cardiovascular medicine and haematology |
| Research Field: | Respiratory diseases |
| Objective Division: | Health |
| Objective Group: | Public health (excl. specific population health) |
| Objective Field: | Public health (excl. specific population health) not elsewhere classified |
| UTAS Author: | Zosky, GR (Professor Graeme Zosky) |
| ID Code: | 89441 |
| Year Published: | 2014 |
| Web of Science® Times Cited: | 27 |
| Deposited By: | Medicine |
| Deposited On: | 2014-03-05 |
| Last Modified: | 2017-11-06 |
| Downloads: | 0 |
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