Klekociuk, SZ and Summers, MJ, Exploring the validity of mild cognitive impairment (MCI) subtypes: Multiple-domain amnestic MCI is the only identifiable subtype at longitudinal follow-up, Journal of Clinical and Experimental Neuropsychology, 36, (3) pp. 290-301. ISSN 1380-3395 (2014) [Refereed Article]
Copyright 2014 Taylor & Francis
Background: Epidemiological research exploring risk factors for Alzheimer’s dementia resulted in the identification of the mild cognitive impairment (MCI) profile. Subsequently, distinct subtypes of MCI have been proposed; however, the validity of these as diagnostic entities remains uncertain.
Design and participants: The aim of the present study was to examine the longitudinal neuropsychological profiles of MCI subtypes. A total of 118 adults aged 60–90 years were classified at screening as amnestic (a-MCI), nonamnestic (na-MCI), and multiple-domain amnestic (a-MCI+) and were assessed at two time points across 20 months on a comprehensive neuropsychological assessment battery.
Results: The a-MCI+ group displayed the poorest performance of all groups in terms of episodic memory, working memory, attention, and executive functioning.
Conclusions: These findings suggest that the a-MCI+ subtype is the only variant that is recognizable via neuropsychological testing. In contrast, the differentiation between single-domain subtypes and healthy controls is difficult and may not be achievable through current neuropsychological assessment practices.
|Item Type:||Refereed Article|
|Keywords:||mild cognitive impairment, longitudinal, neuropsychological, multiple-domain, amnestic|
|Research Division:||Psychology and Cognitive Sciences|
|Research Field:||Biological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology)|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Neurodegenerative Disorders Related to Ageing|
|UTAS Author:||Klekociuk, SZ (Dr Shannon Klekociuk)|
|UTAS Author:||Summers, MJ (Dr Mathew Summers)|
|Web of Science® Times Cited:||7|
|Downloads:||4 View Download Statistics|
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