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Exploring the validity of mild cognitive impairment (MCI) subtypes: Multiple-domain amnestic MCI is the only identifiable subtype at longitudinal follow-up
Citation
Klekociuk, SZ and Summers, MJ, Exploring the validity of mild cognitive impairment (MCI) subtypes: Multiple-domain amnestic MCI is the only identifiable subtype at longitudinal follow-up, Journal of Clinical and Experimental Neuropsychology, 36, (3) pp. 290-301. ISSN 1380-3395 (2014) [Refereed Article]
Copyright Statement
Copyright 2014 Taylor & Francis
DOI: doi:10.1080/13803395.2014.890699
Abstract
Background: Epidemiological research exploring risk factors for Alzheimer’s dementia resulted in the identification of the mild cognitive impairment (MCI) profile. Subsequently, distinct subtypes of MCI have been proposed; however, the validity of these as diagnostic entities remains uncertain.
Design and participants: The aim of the present study was to examine the longitudinal neuropsychological profiles of MCI subtypes. A total of 118 adults aged 60–90 years were classified at screening as amnestic (a-MCI), nonamnestic (na-MCI), and multiple-domain amnestic (a-MCI+) and were assessed at two time points across 20 months on a comprehensive neuropsychological assessment battery.
Results: The a-MCI+ group displayed the poorest performance of all groups in terms of episodic memory, working memory, attention, and executive functioning.
Conclusions: These findings suggest that the a-MCI+ subtype is the only variant that is recognizable via neuropsychological testing. In contrast, the differentiation between single-domain subtypes and healthy controls is difficult and may not be achievable through current neuropsychological assessment practices.
Item Details
Item Type: | Refereed Article |
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Keywords: | mild cognitive impairment, longitudinal, neuropsychological, multiple-domain, amnestic |
Research Division: | Psychology |
Research Group: | Biological psychology |
Research Field: | Behavioural neuroscience |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Klekociuk, SZ (Dr Shannon Klekociuk) |
UTAS Author: | Summers, MJ (Dr Mathew Summers) |
ID Code: | 89439 |
Year Published: | 2014 |
Web of Science® Times Cited: | 11 |
Deposited By: | Psychology |
Deposited On: | 2014-03-05 |
Last Modified: | 2017-11-06 |
Downloads: | 4 View Download Statistics |
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