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Vancomycin minimum inhibitory concentration, host comorbidities and mortality in Staphylococcus aureus bacteraemia

Citation

Holmes, NE and Turnidge, JD and Munckhof, WJ and Robinson, JO and Korman, TM and O'Sullivan, MVN and Anderson, TL and Roberts, SA and Warren, SJC and Gao, W and Johnson, PDR and Howden, BP, Vancomycin minimum inhibitory concentration, host comorbidities and mortality in Staphylococcus aureus bacteraemia, Clinical Microbiology and Infection, 19, (12) pp. 1163-1168. ISSN 1198-743X (2013) [Refereed Article]

Copyright Statement

Copyright 2013 The Authors Clinical Microbiology and Infection Copyright 2013 European Society of Clinical Microbiology and Infectious Diseases

DOI: doi:10.1111/1469-0691.12168

Abstract

We reported an association between elevated vancomycin MIC and 30-day mortality in patients with Staphylococcus aureus bacteraemia (SAB), including patients with methicillin-susceptible S. aureus (MSSA) treated with flucloxacillin. A detailed analysis of comorbidities and disease severity scores in the same cohort of patients was performed to ascertain if unknown clinical parameters may have influenced these results. The association between elevated vancomycin MIC and 30-day mortality in SAB remained significant (p 0.001) on multivariable logistic regression analysis even when accounting for clinical factors. In addition, the association persisted when restricting analysis to patients with MSSA bacteraemia treated with flucloxacillin. This suggests that elevated vancomycin MIC is associated with but not causally linked to an organism factor that is responsible for increased mortality.

Item Details

Item Type:Refereed Article
Keywords:bacteraemia, comorbidity, mortality, Staphylococcus aureus, vancomycin minimum inhibitory concentration
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Infectious Diseases
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Infectious Diseases
Author:Anderson, TL (Dr Tara Anderson)
ID Code:89427
Year Published:2013
Web of Science® Times Cited:18
Deposited By:Medicine (Discipline)
Deposited On:2014-03-04
Last Modified:2017-09-05
Downloads:0

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