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Imidazole initiates exsheathing of L3 teladorsagia circumcincta


Brown, S and Neale, JD and Nava-Tirado, M and Simpson, HV and Pedley, KC and Simcock, DC, Imidazole initiates exsheathing of L3 teladorsagia circumcincta, The Journal of Parasitology, 99, (2) pp. 332-336. ISSN 0022-3395 (2013) [Refereed Article]

Copyright Statement

Copyright 2013 American Society of Parasitologists

DOI: doi:10.1645/GE-3051.1


The infective larvae of Teladorsagia circumcincta have a protective sheath that is lost soon after they reach the rumen of the sheep (the definitive host). Incubation in vitro with 50 mM imidazole caused more than 75% of L3 T. circumcincta to begin exsheathing within 2 hr. The initiation of exsheathing was less likely at pH 6.2 than at pH 7.8. The apparent pKa of this process was 7.08, similar to that for the conversion of imidazolium+ to imidazole. Both the extent and the initial rate of exsheathing initiation increased with imidazole concentration (the apparent K was about 50 mM). The initial rate of exsheathing initiation was stimulated by lactose and maltose, but not by some other carbohydrates, and by propylamine and imidazole acetic acid, but not by histidine. © American Society of Parasitologists 2013.

Item Details

Item Type:Refereed Article
Research Division:Biological Sciences
Research Group:Microbiology
Research Field:Microbiology not elsewhere classified
Objective Division:Animal Production and Animal Primary Products
Objective Group:Livestock raising
Objective Field:Sheep for meat
UTAS Author:Brown, S (Dr Simon Brown)
ID Code:89230
Year Published:2013
Deposited By:Health Sciences A
Deposited On:2014-02-27
Last Modified:2015-02-02

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