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Tissue pharmacokinetics of florfenicol in pigs experimentally infected with Actinobacillus pleuropneumoniae

Citation

Liu, JJ and Fung, KF and Chen, ZL and Zeng, ZL and Zhang, J, Tissue pharmacokinetics of florfenicol in pigs experimentally infected with Actinobacillus pleuropneumoniae, European Journal of Drug Metabolism and Pharmacokinetics, 27, (4) pp. 265-271. ISSN 0378-7966 (2002) [Refereed Article]

Copyright Statement

Copyright 2002 Springer-Verlag

DOI: doi:10.1007/BF03192337

Abstract

The aim of this study has been to determine the tissue pharmacokinetic parameters of florfenicol in the pigs experimentally infected with Actinobacillus pleuropneumoniae. 21 crossed-bred (Duroc x Landrace x Yorkshire) local species of pigs were infected experimentally with Actinobacillus pleuropneumoniae serotype 1 and confirmed as typical sub-acute pleuropneumonia. A single dose of 20mg/kg body weight of florfenicol, a novel animal-using antibiotic, was administrated intramuscularly in the pigs and then samples of blood, lung, trachea with bronchi, liver, kidney and muscle were taken at scheduled time points. Drug concentrations were determined by high performance liquid chromatography (HPLC) with an ultraviolet detector via extraction with ethyl acetate under nitrogen flow. The statistic moment theory (SMT) mathematic package was applied to calculate the tissue pharmacokinetic parameters of florfenicol in the infected model. AUC of lung, trachea with bronchi, liver, kidney and muscle were 121.69, 79.37, 81.05, 181.2, and 94.07 mg/l·h, respectively, MRT were from 34.66 to 90.17 h, and t 1/2β from 24.75 to 69.34 h, respectively. Conclusions: Florfenicol was widely distributed in these tissues and maintained the effective therapeutic concentrations especially in the respiratory tract tissues that are the target organs of Actinobacillus pneuropneumoniae. Clinical significance: Tissue pharmacokinetic data could be evidence for regime designing of florfenicol in treatment of porcine pleuropneumonia.

Item Details

Item Type:Refereed Article
Keywords:Tissue pharmacokinetics, florfenicol, pig
Research Division:Agricultural and Veterinary Sciences
Research Group:Veterinary Sciences
Research Field:Veterinary Pharmacology
Objective Division:Animal Production and Animal Primary Products
Objective Group:Livestock Raising
Objective Field:Pigs
Author:Liu, JJ (Dr Johnson Liu)
ID Code:89138
Year Published:2002
Web of Science® Times Cited:9
Deposited By:Pharmacy
Deposited On:2014-02-25
Last Modified:2014-08-04
Downloads:0

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