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Pharmacokinetics of Florfenicol in Healthy Pigs and in Pigs Experimentally Infected with Actinobacillus pleuropneumoniae
Citation
Liu, JJ and Fung, KF and Chen, Z and Zeng, Z and Zhang, J, Pharmacokinetics of Florfenicol in Healthy Pigs and in Pigs Experimentally Infected with Actinobacillus pleuropneumoniae, Antimicrobial Agents and Chemotherapy, (February) pp. 820-823. ISSN 0066-4804 (2003) [Refereed Article]
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Copyright Statement
Copyright 2003 American Society for Microbiology
Official URL: http://aac.asm.org/content/47/2/820.full?sid=e424d...
Abstract
A comparative in vivo pharmacokinetic study of florfenicol was conducted in 18 crossbred pigs infected with
Actinobacillus pleuropneumoniae following intravenous (i.v.), intramuscular (i.m.), or oral (p.o.) administration
of a single dose of 20 mg/kg. The disease model was confirmed by clinical signs, X rays, pathohistologic
examinations, and organism isolation. Florfenicol concentrations in plasma were determined by a validated
high-performance liquid chromatography method with UV detection at a wavelength of 223 nm. Pharmacokinetic
parameters were calculated by using the MCPKP software (Research Institute of Traditional Chinese
Veterinary Medicine, Lanzhou, China). The disposition of florfenicol after a single i.v. bolus was described by
a two-compartment model with values for the half-life at a phase (t1/2a), the half-life at a phase (t1/2a), the area
under the concentration-time curve (AUC 0-), and the volume of distribution at steady state (Vss) of 0.37 h,
2.91 h, 64.86 ug h/ml, and 1.2 liter/kg, respectively. The concentration-time data fitted the one-compartment
(after i.m.) and two-compartment (after p.o.) models with first-order absorption. The values for the maximum
concentration of drug in serum (Cmax), t1/2a, t1/2a, and bioavailability after i.m. and p.o. dosing were 4.00 and
8.11 ug/ml, 0.12 and 3.91 h, 13.88 and 16.53 h, and 122.7 and 112.9%, respectively, for the two models. The study
showed that florfenicol was absorbed quickly and completely, distributed widely, and eliminated slowly in the
infected pigs, and there was no statistically significant difference between the pharmacokinetic profiles for the
infected and healthy pigs.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | Pharmacokinetics; florfenicol; pig; pneumonia |
| Research Division: | Agricultural, Veterinary and Food Sciences |
| Research Group: | Veterinary sciences |
| Research Field: | Veterinary pharmacology |
| Objective Division: | Animal Production and Animal Primary Products |
| Objective Group: | Livestock raising |
| Objective Field: | Pigs |
| UTAS Author: | Liu, JJ (Dr Johnson Liu) |
| ID Code: | 89136 |
| Year Published: | 2003 |
| Deposited By: | Pharmacy |
| Deposited On: | 2014-02-25 |
| Last Modified: | 2022-08-31 |
| Downloads: | 311 View Download Statistics |
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