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Pharmacokinetics of Florfenicol in Healthy Pigs and in Pigs Experimentally Infected with Actinobacillus pleuropneumoniae

Citation

Liu, JJ and Fung, KF and Chen, Z and Zeng, Z and Zhang, J, Pharmacokinetics of Florfenicol in Healthy Pigs and in Pigs Experimentally Infected with Actinobacillus pleuropneumoniae, Antimicrobial Agents and Chemotherapy, (February) pp. 820-823. ISSN 0066-4804 (2003) [Refereed Article]


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Copyright Statement

Copyright 2003 American Society for Microbiology

Official URL: http://aac.asm.org/content/47/2/820.full?sid=e424d...

Abstract

A comparative in vivo pharmacokinetic study of florfenicol was conducted in 18 crossbred pigs infected with Actinobacillus pleuropneumoniae following intravenous (i.v.), intramuscular (i.m.), or oral (p.o.) administration of a single dose of 20 mg/kg. The disease model was confirmed by clinical signs, X rays, pathohistologic examinations, and organism isolation. Florfenicol concentrations in plasma were determined by a validated high-performance liquid chromatography method with UV detection at a wavelength of 223 nm. Pharmacokinetic parameters were calculated by using the MCPKP software (Research Institute of Traditional Chinese Veterinary Medicine, Lanzhou, China). The disposition of florfenicol after a single i.v. bolus was described by a two-compartment model with values for the half-life at  phase (t1/2), the half-life at  phase (t1/2), the area under the concentration-time curve (AUC0), and the volume of distribution at steady state (Vss) of 0.37 h, 2.91 h, 64.86 g  h/ml, and 1.2 liter/kg, respectively. The concentration-time data fitted the one-compartment (after i.m.) and two-compartment (after p.o.) models with first-order absorption. The values for the maximum concentration of drug in serum (Cmax), t1/2, t1/2, and bioavailability after i.m. and p.o. dosing were 4.00 and 8.11 g/ml, 0.12 and 3.91 h, 13.88 and 16.53 h, and 122.7 and 112.9%, respectively, for the two models. The study showed that florfenicol was absorbed quickly and completely, distributed widely, and eliminated slowly in the infected pigs, and there was no statistically significant difference between the pharmacokinetic profiles for the infected and healthy pigs.

Item Details

Item Type:Refereed Article
Keywords:Pharmacokinetics, florfenicol, pig, pneumonia
Research Division:Agricultural and Veterinary Sciences
Research Group:Veterinary Sciences
Research Field:Veterinary Pharmacology
Objective Division:Animal Production and Animal Primary Products
Objective Group:Livestock Raising
Objective Field:Pigs
Author:Liu, JJ (Dr Johnson Liu)
ID Code:89136
Year Published:2003
Deposited By:Pharmacy
Deposited On:2014-02-25
Last Modified:2014-08-04
Downloads:187 View Download Statistics

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