Wang, S and Young, KM, White matter plasticity in adulthood, Neuroscience: An International Journal pp. 1-13. ISSN 0306-4522 (2013) [Refereed Article]
Copyright 2013 IBRO.
CNS white matter is subject to a novel form of neural plasticity which has been termed "myelin plasticity". It is well established that oligodendrocyte generation and the addition of new myelin internodes continue throughout normal adulthood. These new myelin internodes maybe required for the de novo myelination of previously unmyelinated axons, myelin sheath replacement, or even myelin remodeling. Each process could alter axonal conduction velocity, but to what end? We review the changes that occur within the white matter over the lifetime, the known regulators and mediators of white matter plasticity in the mature CNS, and the physiological role this plasticity may play in CNS function.
|Item Type:||Refereed Article|
|Keywords:||white matter, oligodendrocyte, central nervous system, NG2, plasticity, myelination|
|Research Division:||Biomedical and Clinical Sciences|
|Research Field:||Cellular nervous system|
|Objective Division:||Expanding Knowledge|
|Objective Group:||Expanding knowledge|
|Objective Field:||Expanding knowledge in the biological sciences|
|UTAS Author:||Wang, S (Dr Shiwei Wang)|
|UTAS Author:||Young, KM (Associate Professor Kaylene Young)|
|Funding Support:||National Health and Medical Research Council (1030939)|
|Web of Science® Times Cited:||73|
|Deposited By:||Menzies Institute for Medical Research|
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