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White matter plasticity in adulthood

journal contribution
posted on 2023-05-17, 22:21 authored by Wang, S, Kaylene YoungKaylene Young
CNS white matter is subject to a novel form of neural plasticity which has been termed "myelin plasticity". It is well established that oligodendrocyte generation and the addition of new myelin internodes continue throughout normal adulthood. These new myelin internodes maybe required for the de novo myelination of previously unmyelinated axons, myelin sheath replacement, or even myelin remodeling. Each process could alter axonal conduction velocity, but to what end? We review the changes that occur within the white matter over the lifetime, the known regulators and mediators of white matter plasticity in the mature CNS, and the physiological role this plasticity may play in CNS function.

Funding

National Health & Medical Research Council

History

Publication title

Neuroscience: An International Journal

Pagination

1-13

ISSN

0306-4522

Department/School

Menzies Institute for Medical Research

Publisher

Pergamon-Elsevier Science Ltd

Place of publication

The Boulevard, Langford Lane, Kidlington, Oxford, England, Ox5 1Gb

Rights statement

Copyright 2013 IBRO.

Repository Status

  • Restricted

Socio-economic Objectives

Expanding knowledge in the biological sciences

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    University Of Tasmania

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