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Family history of premature coronary heart disease, child cardio-metabolic risk factors and left ventricular mass
Citation
Magnussen, CG and Dwyer, T and Venn, A, Family history of premature coronary heart disease, child cardio-metabolic risk factors and left ventricular mass, Cardiology in the Young, 24, (5) pp. 938-940. ISSN 1047-9511 (2014) [Refereed Article]
Copyright Statement
Copyright 2013 Cambridge University Press
DOI: doi:10.1017/S1047951113001571
Abstract
In a prospective cohort of 181 individuals followed up since childhood - when aged 9, 12 and 15 years - patients with a family history of premature coronary heart disease (n=18) had higher left ventricular mass index in adulthood - at mean age of 31 years - compared with those without (mean±standard error 39.1±1.9 versus 34.6±0.7 g/m2.7, p=0.04). The correlation between adult left ventricular mass index and child triglycerides (r=0.66, p=0.04 versus r=-0.03, p=0.75; pdiff=0.02) and diastolic blood pressure (r=0.65, p=0.02 versus r=0.16, p=0.07; pdiff=0.05) was stronger among those with a family history of coronary heart disease than in those without. Although preliminary, these data suggest that the higher left ventricular mass index among adults with a family history might be explained by their increased susceptibility to child cardio-metabolic risk factors.
Item Details
Item Type: | Refereed Article |
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Keywords: | Family history, risk factors, left ventricular mass, paediatrics |
Research Division: | Health Sciences |
Research Group: | Epidemiology |
Research Field: | Epidemiology not elsewhere classified |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Magnussen, CG (Associate Professor Costan Magnussen) |
UTAS Author: | Venn, A (Professor Alison Venn) |
ID Code: | 88936 |
Year Published: | 2014 (online first 2013) |
Web of Science® Times Cited: | 4 |
Deposited By: | Menzies Institute for Medical Research |
Deposited On: | 2014-02-20 |
Last Modified: | 2017-12-04 |
Downloads: | 0 |
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