In a prospective cohort of 181 individuals followed up since childhood - when aged 9, 12 and 15 years - patients with a family history of premature coronary heart disease (n=18) had higher left ventricular mass index in adulthood - at mean age of 31 years - compared with those without (mean±standard error 39.1±1.9 versus 34.6±0.7 g/m2.7, p=0.04). The correlation between adult left ventricular mass index and child triglycerides (r=0.66, p=0.04 versus r=-0.03, p=0.75; pdiff=0.02) and diastolic blood pressure (r=0.65, p=0.02 versus r=0.16, p=0.07; pdiff=0.05) was stronger among those with a family history of coronary heart disease than in those without. Although preliminary, these data suggest that the higher left ventricular mass index among adults with a family history might be explained by their increased susceptibility to child cardio-metabolic risk factors.

Item Type:	Refereed Article
Keywords:	Family history, risk factors, left ventricular mass, paediatrics
Research Division:	Medical and Health Sciences
Research Group:	Public Health and Health Services
Research Field:	Epidemiology
Objective Division:	Health
Objective Group:	Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:	Cardiovascular System and Diseases
Author:	Magnussen, CG (Dr Costan Magnussen)
Author:	Venn, A (Professor Alison Venn)
ID Code:	88936
Year Published:	2014 (online first 2013)
Web of Science® Times Cited:	3
Deposited By:	Menzies Institute for Medical Research
Deposited On:	2014-02-20
Last Modified:	2017-12-04
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