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GLP-1 increases microvascular recruitment but not glucose uptake in human and rat skeletal muscle


Sjoberg, KA and Holst, JJ and Rattigan, S and Richter, EA and Kiens, B, GLP-1 increases microvascular recruitment but not glucose uptake in human and rat skeletal muscle, American Journal of Physiology: Endocrinology and Metabolism, 306, (4) pp. E355-E362. ISSN 0193-1849 (2014) [Refereed Article]

Copyright Statement

Copyright 2014 American Physiological Society

DOI: doi:10.1152/ajpendo.00283.2013


The insulinotropic gut hormone glucagon-like peptide-1 (GLP-1) has been proposed to have effects on vascular function and glucose disposal. However, whether GLP-1 is able to increase microvascular recruitment (MVR) in humans has not been investigated. GLP-1 was infused in the femoral artery in overnight-fasted, healthy young men. Microvascular recruitment was measured with real-time contrast-enhanced ultrasound and leg glucose uptake by the leg balance technique with and without inhibition of the insulinotropic response of GLP-1 by coinfusion of octreotide. As a positive control, MVR and leg glucose uptake were measured during a hyperinsulinemic-euglycemic clamp. Infusion of GLP-1 caused a rapid increase (P < 0.05) of 20 12% (mean SE) in MVR in the vastus lateralis muscle of the infused leg after 5 min, and MVR further increased to 60 8% above preinfusion levels by 60 min infusion. The effect was slightly slower but similar in magnitude in the noninfused contralateral leg, in which GLP-1 concentration was within the physiological range. Octreotide infusion did not prevent the GLP-1-induced increase in MVR. GLP-1 infusion did not increase leg glucose uptake with or without octreotide coinfusion. GLP-1 infusion in rats increased MVR by 28% (P < 0.05) but did not increase muscle glucose uptake. During the hyperinsulinemic clamp, MVR increased ∼40%, and leg glucose uptake increased 35-fold. It is concluded that GLP-1 in physiological concentrations causes a rapid insulin-independent increase in muscle MVR but does not affect muscle glucose uptake.

Item Details

Item Type:Refereed Article
Keywords:skeletal muscle, microcirculation, glucose uptake, GLP-1
Research Division:Biomedical and Clinical Sciences
Research Group:Clinical sciences
Research Field:Endocrinology
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Rattigan, S (Professor Stephen Rattigan)
ID Code:88788
Year Published:2014
Funding Support:National Health and Medical Research Council (490034)
Web of Science® Times Cited:46
Deposited By:Menzies Institute for Medical Research
Deposited On:2014-02-17
Last Modified:2017-11-02

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