eCite Digital Repository
Plasticity of melanoma in vivo: murine lesions resulting from Trp53, but not Cdk4 or Arf deregulation, display neural transdifferentiation
Citation
Handoko, HY and Boyle, GM and Ferguson, B and Muller, HK and Soyer, HP and Walker, GJ, Plasticity of melanoma in vivo: murine lesions resulting from Trp53, but not Cdk4 or Arf deregulation, display neural transdifferentiation, Pigment Cell and Melanoma Research, 26, (5) pp. 731-734. ISSN 1755-1471 (2013) [Refereed Article]
Copyright Statement
Copyright 2013 John Wiley & Sons A/S
Abstract
We previously noted that melanomas developing in Cdk4R24C/R24C::Tyr-NRAS, Arf−/−::Tyr-NRAS and Trp53F/F::Tyr-Cre(ER)::Tyr-NRAS mice exhibited differences in behaviour in vivo. We investigated this phenomenon using global gene expression profiling of lesions from the respective genotypes. While those from the Cdk4- and Arf-mutant mice exhibited similar profiles, the Trp53F/F::Tyr-Cre(ER)::Tyr-NRAS melanomas were strikingly different, showing relative down-regulation of melanocyte-related genes, and up-regulation of genes related to neural differentiation. Specifically, they highly expressed genes representative of the myelin-producing peripheral oligodendrite (Schwann cell) lineage, although histopathologically the lesions did not exhibit the classical features of schwannoma. As Schwann cell precursors can be a cellular origin of melanocytes, it is unsurprising that plasticity with respect to melanocyte-neural differentiation can occur in melanoma. What is surprising is the genotype proclivity. Comparison of gene expression signatures revealed that melanomas from the Trp53-mutant mice show significant similarities with a subset of aggressive human melanomas with relatively low levels of MITF.
Item Details
Item Type: | Refereed Article |
---|---|
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Oncology and carcinogenesis |
Research Field: | Cancer cell biology |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Muller, HK (Professor Konrad Muller) |
ID Code: | 88737 |
Year Published: | 2013 |
Web of Science® Times Cited: | 7 |
Deposited By: | Medicine |
Deposited On: | 2014-02-13 |
Last Modified: | 2014-05-15 |
Downloads: | 0 |
Repository Staff Only: item control page