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Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization

Citation

Bonnelykke, K and Matheson, MC and Pers, TH and Granell, R and Strachan, DP and Alves, AC and Linneberg, A and Curtin, JA and Warrington, NM and Standl, M and Kerkhof, M and Jonsdottir, I and Bukvic, BK and Kaakinen, M and Sleimann, P and Thorleifsson, G and Thorsteinsdottir, U and Schramm, K and Baltic, S and Kreiner-Moller, E and Simpson, A and St Pourcain, B and Coin, L and Hui, J and Walters, EH and Tiesler, CMT and Duffy, DL and Jones, G and Ring, SM and McArdle, WL and Price, L and Robertson, CF and Pekkanen, J and Tang, CS and Thiering, E and Montgomery, GW and Hartikainen, A-L and Dharmage, SC and Husemoen, LL and Herder, C and Kemp, JP and Elliot, P and James, A and Waldenberger, M and Abramson, MJ and Fairfax, BP and Knight, CJ and Gupta, R and Thompson, PJ and Holt, P and Sly, P and Hirschhorn, JN and Blekic, M and Weidinger, S and Hakonarsson, H and Stefansson, K and Heinrich, J and Postma, DS and Custovic, A and Pennell, CE and Jarvelin, M-R and Koppelman, GH and Timpson, N and Ferreira, MA and Bisgaard, H and Henderson, AJ, Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization, Nature Genetics, 45, (8) pp. 902-906. ISSN 1061-4036 (2013) [Letter or Note in Journal]


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DOI: doi:10.1038/ng.2694

Abstract

Allergen-specific immunoglobulin E (present in allergic sensitization) has a central role in the pathogenesis of allergic disease. We performed the first large-scale genome-wide association study (GWAS) of allergic sensitization in 5,789 affected individuals and 10,056 controls and followed up the top SNP at each of 26 loci in 6,114 affected individuals and 9,920 controls. We increased the number of susceptibility loci with genome-wide significant association with allergic sensitization from three to ten, including SNPs in or near TLR6, C11orf30, STAT6, SLC25A46, HLA-DQB1, IL1RL1, LPP, MYC, IL2 and HLA-B. All the top SNPs were associated with allergic symptoms in an independent study. Risk-associated variants at these ten loci were estimated to account for at least 25% of allergic sensitization and allergic rhinitis. Understanding the molecular mechanisms underlying these associations may provide new insights into the etiology of allergic disease. © 2013 Nature America, Inc. All rights reserved.

Item Details

Item Type:Letter or Note in Journal
Research Division:Biomedical and Clinical Sciences
Research Group:Cardiovascular medicine and haematology
Research Field:Respiratory diseases
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Walters, EH (Professor Haydn Walters)
ID Code:88726
Year Published:2013
Web of Science® Times Cited:184
Deposited By:Medicine
Deposited On:2014-02-13
Last Modified:2014-05-22
Downloads:0

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