Klekociuk, SZ and Summers, MJ, The learning profile of persistent mild cognitive impairment (MCI): a potential diagnostic marker of persistent amnestic MCI, European Journal of Neurology, 21, (3) pp. 470-477. ISSN 1468-1331 (2014) [Refereed Article]
Copyright 2013 The Authors
Background and purpose: Previous research examining mild cognitive impairment (MCI) has highlighted the heterogeneity of outcome in MCI sufferers. MCI is associated with greater risk of progression to dementia; however, a substantial proportion of those identified with MCI have alternative outcomes including recovery to unimpaired status. This heterogeneity may in part reflect insufficient sensitivity and specificity in identifying subclinical memory impairment.
Method: The present study examined learning in a sample of 109 adults aged 61–91 years with persistent amnestic MCI, persistent non-amnestic MCI, recovered MCI and healthy controls. At the final assessment point, learning for words recalled across each trial of the Rey Auditory Verbal Learning Test was examined for each group.
Results: It was found that persistent amnestic MCI participants displayed significantly lower learning compared with recovered MCI and healthy control groups.
Discussion: The results of this study indicated that poor learning across trials may be a defining feature of persistent amnestic MCI. Further research is required to establish the predictive utility of within trial list learning performance to identify individuals with persistent and progressive variants of MCI.
|Item Type:||Refereed Article|
|Keywords:||diagnosis, episodic memory, learning, mild cognitive impairment, recovery of function, stability|
|Research Group:||Biological psychology|
|Research Field:||Behavioural neuroscience|
|Objective Group:||Clinical health|
|Objective Field:||Clinical health not elsewhere classified|
|UTAS Author:||Klekociuk, SZ (Dr Shannon Klekociuk)|
|UTAS Author:||Summers, MJ (Dr Mathew Summers)|
|Web of Science® Times Cited:||6|
|Downloads:||2 View Download Statistics|
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