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Role of Chemokine Ligand CCL20 and its Receptor CCR6 in lntestinal Inflammation

journal contribution
posted on 2023-05-22, 23:41 authored by Basheer, W, Kunde, DA, Rajaraman Eri
Chemokines are important players in the immune system with individual chemokine axes demonstrating significant associations with numerous inflammatory disorders. The chemokine receptor CCR6 and its ligand CCL20 are reported to be involved in the pathogenesis of inflammatory bowel disease, however the exact mechanism remains elusive. The Ccr6gene has been identified as a susceptibility gene in Crohn’s disease, while the expression of its ligand, CCL20 is up regulated following inflammatory stimulus in the intestine. The identification of the role of CCR6-CCL20 axis during the inflammation will shed valuable light into the pathogenesis of IBD as well as providing a potential therapeutic target for treatment for IBD.

History

Publication title

Immunology and Infectious Diseases

Pagination

30-37

ISSN

2333-2719

Department/School

School of Health Sciences

Publisher

Horizon Research Publishing

Place of publication

USA

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

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