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Approaches to Enhancing the Sensitivity of Carbohydrate Separations in Capillary Electrophoresis

Citation

Breadmore, MC, Approaches to Enhancing the Sensitivity of Carbohydrate Separations in Capillary Electrophoresis, Capillary Electrophoresis of Biomolecules: Methods and Protocols, Humana Press, N Volpi and F Maccari (ed), New York, USA, pp. 27-43. ISBN 978-1-62703-295-7 (2013) [Research Book Chapter]

Copyright Statement

Copyright 2013 Springer Science+Business Media

DOI: doi:10.1007/978-1-62703-296-4_3

Abstract

Electrophoresis in both capillaries (CE) and microchips (ME) is an extremely powerful liquid phase-separation technique that is indispensable for the separation of carbohydrates. It is capable of separating both small mono- and disaccharides, through to more complex oligo- and polysaccharides, with high resolution, but as with all CE and ME separations, the detection limits are often inferior to those that can be achieved with liquid chromatographic methods. One avenue to address this is to use an on-line concentration strategy. Various approaches have been developed over the past 20 years, and this chapter will highlight their application to improve the sensitivity of carbohydrate separations in both CE and ME.

Item Details

Item Type:Research Book Chapter
Keywords:electrophoresis, carbohydrates
Research Division:Chemical Sciences
Research Group:Analytical Chemistry
Research Field:Separation Science
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Chemical Sciences
Author:Breadmore, MC (Professor Michael Breadmore)
ID Code:88422
Year Published:2013
Funding Support:Australian Research Council (DP0984745)
Deposited By:Austn Centre for Research in Separation Science
Deposited On:2014-02-03
Last Modified:2014-08-25
Downloads:0

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