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Hypolipidaemic effect of crude extract from Carpobrotus rossii (pigface) in healthy rats

Citation

Pirie, AD and Davies, NW and Ahuja, KDK and Adams, MJ and Shing, CM and Narkowicz, C and Jacobson, GA and Geraghty, DP, Hypolipidaemic effect of crude extract from Carpobrotus rossii (pigface) in healthy rats, Food and Chemical Toxicology, 66 pp. 134-139. ISSN 0278-6915 (2014) [Refereed Article]

Copyright Statement

Copyright 2014 Elsevier

DOI: doi:10.1016/j.fct.2014.01.034

Abstract

Carpobrotus rossii (CR) was used by the Aboriginal population and early European settlers both as a food and therapeutic agent. Based on the presence of flavonoids in CR and results from our previous in vitro investigations, this study aimed to determine whether consumption of CR crude leaf extract: (a) affected lipoprotein profile, resting glucose, systolic blood pressure and vascular function, and (b) produced toxic effects (haematological measures, organ weight) in healthy rats. Male Hooded-Wistar rats (∼230 g) were supplemented for 4 weeks with CR extract in their drinking water (35 mg/kg body weight daily). CR extract produced a significant decrease (18%, p = 0.033) in atherogenic lipoproteins (but not high density lipoprotein). CR supplemented animals showed no signs of haematological toxicity and body and organ weight, daily fluid and food consumption and in vitro vascular responsiveness were similar for both groups. CR also increased (40%, p = 0.049) the renal concentration of 3-hydroxy-3-methylglutaric acid (HMG), consistent with HMG-containing CR flavonoids being bioavailable, and therefore possessing the potential to interfere with cholesterol synthesis pathways. CR extract appears to be safe to ingest and may reduce cardiovascular risk.

Item Details

Item Type:Refereed Article
Keywords:cardiovascular, lipid, toxicology, Carpobrotus spp., polyphenolic, traditional medicine, flavonoid, flavonol
Research Division:Medical and Health Sciences
Research Group:Pharmacology and Pharmaceutical Sciences
Research Field:Basic Pharmacology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Cardiovascular System and Diseases
Author:Pirie, AD (Mr Adam Pirie)
Author:Davies, NW (Associate Professor Noel Davies)
Author:Ahuja, KDK (Dr Kiran Ahuja)
Author:Adams, MJ (Dr Murray Adams)
Author:Shing, CM (Dr Cecilia Kitic)
Author:Narkowicz, C (Dr Christian Narkowicz)
Author:Jacobson, GA (Dr Glenn Jacobson)
Author:Geraghty, DP (Professor Dominic Geraghty)
ID Code:88232
Year Published:2014
Deposited By:Health Sciences A
Deposited On:2014-01-21
Last Modified:2017-11-01
Downloads:0

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