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Sources of pain in osteoarthritis: implications for therapy

Citation

Jones, G, Sources of pain in osteoarthritis: implications for therapy, International Journal of Clinical Rheumatology, 8, (3) pp. 335-345. ISSN 1758-4272 (2013) [Refereed Article]

Copyright Statement

Copyright 2013 Future Medicine Ltd

DOI: doi:10.2217/IJR.13.19

Abstract

Osteoarthritis is the leading musculoskeletal cause of disability in western society. Despite this, it is still difficult to gain a precise definition of what osteoarthritis actually is. It is well known that there is a modest correlation between x-ray changes and pain. However, for knee joint structure there is largely consistent evidence that bone marrow lesions, synovitis/effusions and cartilage defects are associated with knee pain and cartilage loss. In addition, muscle strength and obesity predict pain even in the absence of structural knee pathology. Finally, the pain system itself is involved with both pain processing and genetic factors implicated in recent studies. These improvements in basic science have greatly enhanced our understanding that osteoarthritis is an umbrella term for a number of pathways leading to very similar pain and structural outcomes; these outcomes are leading to lesion-specific therapies, which indicate the importance of trying to pinpoint causes of pain in the individual.

Item Details

Item Type:Refereed Article
Keywords:epidemiology, osteoarthritis, pain, therapy
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Rheumatology and Arthritis
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Skeletal System and Disorders (incl. Arthritis)
Author:Jones, G (Professor Graeme Jones)
ID Code:88141
Year Published:2013
Deposited By:Menzies Institute for Medical Research
Deposited On:2014-01-14
Last Modified:2014-06-13
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