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The challenge of chronic lung disease in HIV-infected children and adolescents


Weber, HC and Gie, RP and Cotton, MF, The challenge of chronic lung disease in HIV-infected children and adolescents, International AIDS Society. Journal, 16 Article 18633. ISSN 1758-2652 (2013) [Refereed Article]


Copyright Statement

Copyright 2013 Weber HC et al; licensee International AIDS Society. This is an open access article distributed under the terms of the Creative Commons Attribution 3.0 Unported (CC BY 3.0) Licence (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

DOI: doi:10.7448/IAS.16.1.18633


Until recently, little attention has been given to chronic lung disease (CLD) in HIV-infected children. As the HIV epidemic matures in sub-Saharan Africa, adolescents who acquired HIV by vertical transmission are presenting to health services with chronic diseases. The most common is CLD, which is often debilitating. This review summarizes the limited data available on the epidemiology, pathophysiology, clinical picture, special investigations and management of CLD in HIV-infected adolescents. A number of associated conditions: lymphocytic interstitial pneumonitis, tuberculosis and bronchiectasis are well described. Other pathologies such as HIV-associated bronchiolitis obliterans resulting in non-reversible airway obstruction, has only recently been described. In this field, there are many areas of uncertainty needing urgent research. These areas include the definition of CLD, pathophysiological mechanisms and common pathologies responsible. Very limited data are available to formulate an effective plan of investigation and management.

Item Details

Item Type:Refereed Article
Keywords:HIV, LIP, adolescent, bronchiectasis, children, chronic lung disease, tuberculosis (TB)
Research Division:Biomedical and Clinical Sciences
Research Group:Medical microbiology
Research Field:Medical virology
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Weber, HC (Associate Professor Heinrich Weber)
ID Code:88128
Year Published:2013
Web of Science® Times Cited:20
Deposited By:Rural Clinical School
Deposited On:2014-01-13
Last Modified:2017-11-06
Downloads:307 View Download Statistics

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