eCite Digital Repository

A retrospective chart review of the use of rituximab for the treatment of rheumatoid arthritis in Australian rheumatology practice

Citation

Nicholls, D and Zochling, J and Boers, A and Champion, G and Mathers, D and Riordan, J and Youssef, P and Scott, J and Griffiths, H, A retrospective chart review of the use of rituximab for the treatment of rheumatoid arthritis in Australian rheumatology practice, International Journal of Rheumatic Diseases, 17, (7) pp. 755-761. ISSN 1756-1841 (2014) [Refereed Article]

Copyright Statement

Copyright 2013 Asia Pacific League of Associations for Rheumatology and Wiley Publishing Asia Pty Ltd

DOI: doi:10.1111/1756-185X.12164

Abstract

Aim: Rituximab is one of nine biologic agents approved for the treatment of rheumatoid arthritis (RA) in Australia. The primary study objective was to analyze the factors that lead to the therapeutic decision to use rituximab in RA. Method: A cross-sectional, retrospective chart review was conducted to identify patients who were treated with rituximab and to evaluate their response to treatment. Results: Factors influencing the prescription of rituximab were identified. The most commonly reported reason for prescribing rituximab was the presence of comorbidities and the presence of seropositive disease. Median rituximab treatment duration was 32.5 months and mean number of treatment cycles was 4.1. Disease activity scores showed significant improvement from baseline to most recent visit. Rituximab treatment was well-tolerated in this group of RA patients. Conclusions: Rituximab was effective in a refractory group of RA patients and appears to be safe in a population with a high prevalence of comorbidities, including malignancy and recurrent infections/bronchiectasis. This study may assist rheumatologists in selecting appropriately targeted therapy in RA. © 2013 Asia Pacific League of Associations for Rheumatology and Wiley Publishing Asia Pty Ltd.

Item Details

Item Type:Refereed Article
Keywords:rituximab, rheumatoid arthritis, Australia, chart review, comorbidities
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Rheumatology and Arthritis
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Skeletal System and Disorders (incl. Arthritis)
Author:Zochling, J (Dr Jane Zochling)
ID Code:88108
Year Published:2014 (online first 2013)
Deposited By:Menzies Institute for Medical Research
Deposited On:2014-01-13
Last Modified:2016-12-05
Downloads:0

Repository Staff Only: item control page