Jin, X and Beguerie, JR and Zhang, W and Blizzard, L and Otahal, P and Jones, G and Ding, C, Circulating C reactive protein in osteoarthritis: a systematic review and meta-analysis, ARD Online, 74 pp. 703-710. ISSN 1468-2060 (2015) [Refereed Article]
Copyright 2013 the authors
Background: There is emerging evidence that the development and progression of osteoarthritis (OA) is associated with inflammation. C reactive protein (CRP), a systemic marker for inflammation, may be elevated in OA patients but the evidence is conflicting.
Objective: To systematically review the literature for the relationship between serum CRP levels measured by a high sensitivity method (high sensitive CRP (hs-CRP)) and OA, as well as the correlation between circulating CRP levels and OA phenotypes.
Methods: MEDLINE, EMBASE and CINAHL databases were systematically searched from January 1992 to December 2012. Studies were included when they met the inclusion criteria and data from studies were extracted. Two independent reviewers assessed study quality using a modified Newcastle-Ottawa Quality Assessment Scale. Meta-analyses were performed to pool available data from included studies.
Results: 32 studies met the inclusion criteria. Serum hs-CRP levels in OA were modestly but statistically significantly higher than controls (mean difference=1.19 mg/L, 95% CI 0.64 to 1.73, p<0.001) with significant heterogeneity between studies. Levels were significantly associated with pain (r=0.14, 95% CI 0.09 to 0.20, p<0.001) and decreased physical function (r=0.25, 95% CI 0.13 to 0.39, p<0.001). No significant associations were found between hs-CRP levels and radiographic OA.
Conclusion: Low-grade systemic inflammation may play a greater role in symptoms rather than radiographic changes in OA.
|Item Type:||Refereed Article|
|Keywords:||Epidemiology, Inflammation, Osteoarthritis|
|Research Division:||Medical and Health Sciences|
|Research Group:||Clinical Sciences|
|Research Field:||Rheumatology and Arthritis|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Skeletal System and Disorders (incl. Arthritis)|
|Author:||Jin, X (Mr Xingzhong Jin)|
|Author:||Blizzard, L (Professor Leigh Blizzard)|
|Author:||Otahal, P (Mr Petr Otahal)|
|Author:||Jones, G (Professor Graeme Jones)|
|Author:||Ding, C (Professor Chang-Hai Ding)|
|Year Published:||2015 (online first 2013)|
|Web of Science® Times Cited:||54|
|Deposited By:||Menzies Institute for Medical Research|
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