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Regional respiratory inflation and deflation pressure-volume curves determined by electrical impedance tomography

Citation

Frerichs, I and Dargaville, PA and Rimensberger, PC, Regional respiratory inflation and deflation pressure-volume curves determined by electrical impedance tomography, Physiological Measurement, 34, (6) pp. 567-577. ISSN 0967-3334 (2013) [Refereed Article]

Copyright Statement

Copyright 2013 Institute of Physics and Engineering in Medicine

DOI: doi:10.1088/0967-3334/34/6/567

Abstract

Measurement of regional lung volume changes during a quasi-static pressure-volume (PV) manoeuvre using electrical impedance tomography (EIT) could be used to assess regional respiratory system mechanics and to determine optimal ventilator settings in individual patients. Using this approach, we studied regional respiratory system mechanics in healthy and lung-injured animals, before and after surfactant administration during inflation and deflation PV manoeuvres. The comparison of the EIT-derived regional PV curves in ventral, middle and dorsal regions of the right and left lungs showed not only different amounts of hysteresis in these regions but also marked differences among different landmark pressures calculated on the inflation and deflation limbs of the curves. Regional pressures at maximum compliance as well as the lower and upper pressures of maximum compliance change differed between the inflation and deflation and increased from ventral to dorsal regions in all lung conditions. All these pressure values increased in the injured and decreased in the surfactant treated lungs. Examination of regional respiratory system mechanics using EIT enables the assessment of spatial and temporal heterogeneities in the ventilation distribution. Characteristic landmarks on the inflation and especially on the deflation limb of regional PV curves may become useful measures for guiding mechanical ventilation.

Item Details

Item Type:Refereed Article
Keywords:EIT, lung impedance, respiratory system mechanics, respiratory system compliance, acute lung injury
Research Division:Medical and Health Sciences
Research Group:Paediatrics and Reproductive Medicine
Research Field:Paediatrics
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Respiratory System and Diseases (incl. Asthma)
Author:Dargaville, PA (Professor Peter Dargaville)
ID Code:88028
Year Published:2013
Web of Science® Times Cited:10
Deposited By:Menzies Institute for Medical Research
Deposited On:2014-01-07
Last Modified:2017-11-06
Downloads:0

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