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Anthropogenic selection enhances cancer evolution in Tasmanian devil tumours

Citation

Ujvari, B and Pearse, A-M and Swift, K and Hodson, P and Hua, B and Pyecroft, S and Taylor, R and Hamede, R and Jones, M and Belov, K and Madsen, T, Anthropogenic selection enhances cancer evolution in Tasmanian devil tumours, Evolutionary Applications, 7, (2) pp. 260-265. ISSN 1752-4571 (2013) [Refereed Article]


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Licenced under Creative Commons Attribution 3.0 Unported (CC BY 3.0) http://creativecommons.org/licenses/by/3.0/

DOI: doi:10.1111/eva.12117

Abstract

The Tasmanian Devil Facial Tumour Disease (DFTD) provides a unique opportunity to elucidate the long-term effects of natural and anthropogenic selection on cancer evolution. Since first observed in 1996, this transmissible cancer has caused local population declines by >90%. So far, four chromosomal DFTD variants (strains) have been described and karyotypic analyses of 253 tumours showed higher levels of tetraploidy in the oldest strain. We propose that increased ploidy in the oldest strain may have evolved in response to effects of genomic decay observed in asexually reproducing organisms. In this study, we focus on the evolutionary response of DFTD to a disease suppression trial. Tumours collected from devils subjected to the removal programme showed accelerated temporal evolution of tetraploidy compared with tumours from other populations where no increase in tetraploid tumours were observed. As ploidy significantly reduces tumour growth rate, we suggest that the disease suppression trial resulted in selection favouring slower growing tumours mediated by an increased level of tetraploidy. Our study reveals that DFTD has the capacity to rapidly respond to novel selective regimes and that disease eradication may result in novel tumour adaptations, which may further imperil the long-term survival of the world’s largest carnivorous marsupial.

Item Details

Item Type:Refereed Article
Keywords:cancer evolution, genomic decay, Tasmanian devil facial tumour disease, disease ecology
Research Division:Biological Sciences
Research Group:Genetics
Research Field:Molecular Evolution
Objective Division:Environment
Objective Group:Flora, Fauna and Biodiversity
Objective Field:Forest and Woodlands Flora, Fauna and Biodiversity
Author:Hamede, R (Mr Rodrigo Hamede Ross)
Author:Jones, M (Associate Professor Menna Jones)
ID Code:88022
Year Published:2013
Web of Science® Times Cited:8
Deposited By:Zoology
Deposited On:2014-01-07
Last Modified:2017-10-31
Downloads:192 View Download Statistics

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