Negishi, K and Negishi, T and Haluska, BA and Hare, JL and Plana, JC and Marwick, TH, Use of speckle strain to assess left ventricular responses to cardiotoxic chemotherapy and cardioprotection, European Heart Journal Cardiovascular Imaging, 15, (3) pp. 324-331. ISSN 2047-2404 (2014) [Refereed Article]
Copyright 2013 the authors
Aims: The variability of ejection fraction (EF) poses a problem in the assessment of left ventricular (LV) function in patients receiving potentially cardiotoxic chemotherapy. We sought to use global longitudinal strain (GLS) to compare LV responses to various cardiotoxic chemotherapy regimens and to examine the response to cardioprotection with beta-blockers (BB) in patients showing subclinical myocardial damage.
Methods and Results We studied 159 patients (49 ± 14 year, 127 women) receiving anthracycline (group A, n = 53, 46 ± 17 year), trastuzumab (group T, n = 61, 53 ± 12 year), or trastuzumab after anthracyclines (group AT, n = 45, 46 ± 9 year). LV indices [ejection fraction (EF), mitral annular systolic velocity, and GLS] were measured at baseline and follow-up (7 ± 7 months). Patients who decreased GLS by ≥ 11% were followed for another 6 months; initiation of BB was at the discretion of the clinician. Anthracycline dose was similar between group A and group AT (213 ± 118 vs. 216 ± 47 mg/m2, P = 0.85). Although ΔEF was similar among the groups, attenuation of GLS was the greatest in group AT (group A, 0.7 ± 2.8% shortening; T, 1.1 ± 2.7%; and AT, 2.0 ± 2.3%; P = 0.003, after adjustment). Of 52 patients who decreased GLS by ≥ −11%, 24 were treated with BB and 28 were not. GLS improved in BB groups (from −17.6 ± 2.3 to −19.8 ± 2.6%, P < 0.001) but not in non-BB groups (from −18.0 ± 2.0 to −19.0 ± 3.0%, P = 0.08). Effects of BB were similar with all regimens.
Conclusions GLS is an effective parameter for identifying systolic dysfunction (which appears worst with combined anthracycline and trastuzumab therapy) and responds to cardioprotection in patients administered beta-blockers.
|Item Type:||Refereed Article|
|Keywords:||beta-blocker, cardiotoxicity, trastuzumab, anthracyclines, strain|
|Research Division:||Medical and Health Sciences|
|Research Group:||Cardiorespiratory Medicine and Haematology|
|Research Field:||Cardiology (incl. Cardiovascular Diseases)|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Cardiovascular System and Diseases|
|UTAS Author:||Negishi, K (Dr Kazuaki Negishi)|
|UTAS Author:||Marwick, TH (Professor Tom Marwick)|
|Year Published:||2014 (online first 2013)|
|Web of Science® Times Cited:||81|
|Deposited By:||Menzies Institute for Medical Research|
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