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Effects of bromocriptine on lactation and plasma progesterone in Bettongia gaimardi, a Tasmanian macropodid marsupial

Citation

Rose, RW and Jones, SM and Macfadyen, AS, Effects of bromocriptine on lactation and plasma progesterone in Bettongia gaimardi, a Tasmanian macropodid marsupial, Reproduction, Fertility and Development, 8, (7) pp. 1061-1067. ISSN 1031-3613 (1996) [Refereed Article]

DOI: doi:10.1071/RD9961061

Abstract

Many macropodids exhibit lactational quiescence during which an embryo produced at post-partum mating is retained as a blastocyst in utero while a pouch young is sucking. The sucking stimulus maintains secretion of prolactin which may in some species inhibit the activity of the corpus luteum and, hence, the development of the embryo. When the sucking frequency decreases, the blastocyst resumes development. In the present study, the dopamine agonist bromocriptine, which in many mammals results in decreased secretion of prolactin from the pituitary gland, was administered to the Tasmanian bettong (Bettongia gaimardi) at two different doses (12.5 mg kg-1 and 5 mg kg-1). Although lactation was affected by both doses, as evidenced by slower growth of the pouch young or their loss, in only two cases did the quiescent blastocyst activate at the time of injection. This occurred with the highest dose of bromocriptine and was reflected by earlier changes in plasma progesterone concentrations. It is concluded that the Tasmanian bettong is unusual in its lack of sensitivity to bromocriptine.

Item Details

Item Type:Refereed Article
Research Division:Biological Sciences
Research Group:Physiology
Research Field:Physiology not elsewhere classified
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Environmental Sciences
Author:Rose, RW (Associate Professor Randy Rose)
Author:Jones, SM (Professor Susan Jones)
ID Code:8794
Year Published:1996
Web of Science® Times Cited:3
Deposited By:Zoology
Deposited On:1996-08-01
Last Modified:2014-04-17
Downloads:0

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