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Effects of Eyjafjallajökull volcanic ash on innate immune system responses and bacterial growth in vitro

Citation

Monick, MM and Baltrusaitis, J and Powers, LS and Borcherding, JA and Caraballo, JC and Mudunkotuwa, I and Peate, DW and Walters, K and Thompson, JM and Grassian, VH and Gudmundsson, G and Comellas, AP, Effects of Eyjafjallajökull volcanic ash on innate immune system responses and bacterial growth in vitro, Environmental Health Perspectives, 121, (6) pp. 691-698. ISSN 0091-6765 (2013) [Refereed Article]


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2013 Reproduced with permission from Environmental Health Perspectives

DOI: doi:10.1289/ehp.1206004

Abstract

Background: On 20 March 2010, the Icelandic volcano Eyjafjallajökull erupted for the first time in 190 years. Despite many epidemiological reports showing effects of volcanic ash on the respiratory system, there are limited data evaluating cellular mechanisms involved in the response to ash. Epidemiological studies have observed an increase in respiratory infections in subjects and populations exposed to volcanic eruptions. Methods: We physicochemically characterized volcanic ash, finding various sizes of particles, as well as the presence of several transition metals, including iron. We examined the effect of Eyjafjallajökull ash on primary rat alveolar epithelial cells and human airway epithelial cells (20-100 μg/cm2), primary rat and human alveolar macrophages (5-20 μg/cm2), and Pseudomonas aeruginosa (PAO1) growth (3 μg/104 bacteria). Results: Volcanic ash had minimal effect on alveolar and airway epithelial cell integrity. In alveolar macrophages, volcanic ash disrupted pathogen-killing and inflammatory responses. In in vitro bacterial growth models, volcanic ash increased bacterial replication and decreased bacterial killing by antimicrobial peptides. Conclusions: These results provide potential biological plausibility for epidemiological data that show an association between air pollution exposure and the development of respiratory infections. These data suggest that volcanic ash exposure, while not seriously compromising lung cell function, may be able to impair innate immunity responses in exposed individuals.

Item Details

Item Type:Refereed Article
Keywords:bacteria, epithelium, innate immunity, iron, macrophage, volcanic ash
Research Division:Earth Sciences
Research Group:Physical Geography and Environmental Geoscience
Research Field:Natural Hazards
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Earth Sciences
Author:Thompson, JM (Mr Jay Thompson)
ID Code:87901
Year Published:2013
Web of Science® Times Cited:19
Deposited By:Centre for Ore Deposit Research - CODES CoE
Deposited On:2013-12-14
Last Modified:2017-10-30
Downloads:0

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