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Central Hemodynamics Could Explain the Inverse Association Between Height and Cardiovascular Mortality


Reeve, JC and Abhayaratna, WP and Davies, JE and Sharman, JE, Central Hemodynamics Could Explain the Inverse Association Between Height and Cardiovascular Mortality, American Journal of Hypertension, 27, (3) pp. 392-400. ISSN 1941-7225 (2014) [Refereed Article]

Copyright Statement

Copyright 2013 American Journal of Hypertension, Ltd

DOI: doi:10.1093/ajh/hpt222


BACKGROUND: Mechanisms underlying the inverse relationship between height and cardiovascular mortality are unknown but could relate to central hemodynamics. We sought to determine the relation of height to central and peripheral hemodynamics, as well as clinical characteristics. METHODS: The study population was comprised of 1,152 randomly selected community-dwelling adults (aged 67.712.3 years; 48% men). Brachial blood pressure (BP) was recorded by sphygmomanometry; central BP and aortic pulse wave velocity were estimated by applanation tonometry. Stepwise multiple regression analysis was used to determine associations between height and central and peripheral hemodynamics. RESULTS: Height was not significantly associated with aortic pulse wave velocity in men or women. The relationship with height and brachial systolic BP was borderline in women (β = -0.115; P = 0.051) but not significant in men (β = -0.096; P = 0.09). Conversely, central systolic BP, estimated by transfer function (β = -0.139 for men [βM]; β = -0.172 for women [βW]) or radial second systolic peak (β M = -0.239; β W = -0.281), augmentation index at 75 bpm (β M = -0.189; β W = -0.224), and aortic pulse wave timing (β M = 0.224; β W = 0.262) were independently associated with height in both sexes (P < 0.003 for all). Both men and women of greater than median height were less likely to have coronary artery disease (P < 0.05), to have systemic hypertension (P < 0.01), or to be taking vasoactive medication (P < 0.001) compared with participants of less than median height. CONCLUSIONS: Even after correcting for conventional cardiovascular risk factors, taller individuals have more favorable central hemodynamics and reduced evidence of coronary artery disease compared with shorter individuals. These findings may help explain the decreased cardiovascular risk associated with being taller and also have important clinical consequences regarding therapy.

Item Details

Item Type:Refereed Article
Keywords:aortic pulse wave velocity; arterial stiffness; blood pressure; central blood pressure; hypertension
Research Division:Biomedical and Clinical Sciences
Research Group:Cardiovascular medicine and haematology
Research Field:Cardiology (incl. cardiovascular diseases)
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Reeve, JC (Mr Jake Reeve)
UTAS Author:Sharman, JE (Professor James Sharman)
ID Code:87835
Year Published:2014 (online first 2013)
Web of Science® Times Cited:24
Deposited By:Menzies Institute for Medical Research
Deposited On:2013-12-10
Last Modified:2017-11-02

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