A multiplexed dual-secondary column comprehensive two-dimensional gas chromatography approach (GC × 2GC) designed for complex sample analysis is introduced. The approach splits the first-dimension column effluent into two second-dimension columns with different stationary phases, and recombines the two streams into one detector post-separation. The approach produces two single two-dimensional chromatograms for each injection. Careful manipulation of thermal modulator timing parameters combined with a novel contra-directional modulation regime facilitates this approach. A selection of 34 laboratory reference compounds containing n-alkanes, alcohols, aromatic hydrocarbons, ketones, esters and halogenated hydrocarbons were analysed to demonstrate the approach. The dual two-dimensional chromatogram from this single detector system provides complementary information due to the unique selectivity of the three separation columns. The results of this proof-of-principle investigation provide significant impetus for further development of GC × 2GC–MS methodology.

Item Type:	Refereed Article
Keywords:	gas chromatography, comprehensive two-dimensional, dual second-dimension columns, multiplexed, contra-directional
Research Division:	Chemical Sciences
Research Group:	Analytical chemistry
Research Field:	Separation science
Objective Division:	Expanding Knowledge
Objective Group:	Expanding knowledge
Objective Field:	Expanding knowledge in the chemical sciences
UTAS Author:	Savareear, B (Mr Benjamin Savareear)
UTAS Author:	Shellie, RA (Professor Robert Shellie)
ID Code:	87724
Year Published:	2013
Web of Science® Times Cited:	7
Deposited By:	Austn Centre for Research in Separation Science
Deposited On:	2013-12-04
Last Modified:	2017-10-31
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