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Impact of Antidepressants on Cytokine Production of Depressed Patients in Vitro

Citation

Munzer, A and Sack, U and Mergl, R and Schonherr, J and Petersein, C and Bartsch, S and Kirkby, KC and Bauer, K and Himmerich, H, Impact of Antidepressants on Cytokine Production of Depressed Patients in Vitro, Toxins, 5, (11) pp. 2227-2240. ISSN 2072-6651 (2013) [Refereed Article]


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Licenced under Creative Commons Attribution 3.0 Unported (CC BY 3.0) http://creativecommons.org/licenses/by/3.0/

DOI: doi:10.3390/toxins5112227

Abstract

The interplay between immune and nervous systems plays a pivotal role in the pathophysiology of depression. In depressive episodes, patients show increased production of pro-inflammatory cytokines such as interleukin (IL)-1β and tumor necrosis factor (TNF)-α. There is limited information on the effect of antidepressant drugs on cytokines, most studies report on a limited sample of cytokines and none have reported effects on IL-22. We systematically investigated the effect of three antidepressant drugs, citalopram, escitalopram and mirtazapine, on secretion of cytokines IL-1β, IL-2, IL-4, IL-6, IL-17,IL-22 and TNF-α in a whole blood assay in vitro, using murine anti-human CD3 monoclonal antibody OKT3, and 5C3 monoclonal antibody against CD40, to stimulate T and B cells respectively. Citalopram increased production of IL-1β, IL-6, TNF-α and IL-22. Mirtazapine increased IL-1β, TNF-α and IL-22. Escitalopram decreased IL-17 levels. The influence of antidepressants on IL-2 and IL-4 levels was not significant for all three drugs. Compared to escitalopram, citalopram led to higher levels of IL-1β, IL-6, IL-17 and IL-22; and mirtazapine to higher levels of IL-1β, IL-17, IL-22 and TNF-α. Mirtazapine and citalopram increased IL-22 production. The differing profile of cytokine production may relate to differences in therapeutic effects, risk of relapse and side effects.

                 

Item Details

Item Type:Refereed Article
Keywords:cytokines, depression, antidepressants, citalopram, escitalopram, mirtazapine
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Psychiatry (incl. Psychotherapy)
Objective Division:Health
Objective Group:Public Health (excl. Specific Population Health)
Objective Field:Mental Health
Author:Kirkby, KC (Professor Kenneth Kirkby)
ID Code:87720
Year Published:2013
Web of Science® Times Cited:48
Deposited By:Medicine (Discipline)
Deposited On:2013-12-04
Last Modified:2017-11-02
Downloads:223 View Download Statistics

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