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The activation level of the TNF family receptor, Edar, determines cusp number and tooth number during tooth development

Citation

Tucker, AS and Headon, DJ and Courtney, J and Overbeek, P and Sharpe, PT, The activation level of the TNF family receptor, Edar, determines cusp number and tooth number during tooth development, Developmental Biology: An International Journal, 268, (1) pp. 185-94. ISSN 0012-1606 (2004) [Refereed Article]

DOI: doi:10.1016/j.ydbio.2003.12.019

Abstract

Mutations in members of the ectodysplasin (TNF-related) signalling pathway, EDA, EDAR, and EDARADD in mice and humans produce an ectodermal dysplasia phenotype that includes missing teeth and smaller teeth with reduced cusps. Using the keratin 14 promoter to target expression of an activated form of Edar in transgenic mice, we show that expression of this transgene is able to rescue the tooth phenotype in Tabby (Eda) and Sleek (Edar) mutant mice. High levels of expression of the transgene in wild-type mice result in molar teeth with extra cusps, and in some cases supernumerary teeth, the opposite of the mutant phenotype. The level of activation of Edar thus determines cusp number and tooth number during tooth development

Item Details

Item Type:Refereed Article
Research Division:Biological Sciences
Research Group:Biochemistry and Cell Biology
Research Field:Cell Development, Proliferation and Death
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Oro-Dental Disorders
Author:Courtney, J (Dr Jo-Maree Courtney)
ID Code:87620
Year Published:2004
Web of Science® Times Cited:85
Deposited By:Medicine (Discipline)
Deposited On:2013-11-27
Last Modified:2013-11-27
Downloads:0

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