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The Ectodysplasin and NFkappaB signalling pathways in odontogenesis

journal contribution
posted on 2023-05-17, 20:43 authored by Jo-Maree CourtneyJo-Maree Courtney, Blackburn, J, Sharpe, PT
Hypohidrotic ectodermal dysplasia (HED) is a congenital disorder affecting organs of ectodermal origin including teeth, hair and sweat glands. Defects in Ectodysplasin (tabby), Edar (downless) and Edar associated death domain (Edaradd) (crinkled) cause HED in both humans and mice. Ectodysplasin is a tumour necrosis factor (TNF) superfamily member whose downstream signalling is transduced by the inhibitor of kappaB kinase (IKK) complex and inhibitors of kappaB (IkappaB) to activate the transcription factor NFkappaB. NFkappaB signalling is involved in a wide range of cellular processes and at each stage the different family members must be tightly regulated for each function. Recent data have demonstrated the importance of this signalling pathway in odontogenesis, particularly in the formation of cusps. Here we review recent advances in our understanding of Ectodysplasin/NFkappaB signalling in tooth development and in particular the central role of the IKK complex.

History

Publication title

Archives of Oral Biology: A Multidisciplinary Journal in Oral Research

Volume

50

Pagination

159-63

ISSN

0003-9969

Department/School

Tasmanian School of Medicine

Publisher

Pergamon-Elsevier Science Ltd

Place of publication

The Boulevard, Langford Lane, Kidlington, Oxford, England, Ox5 1Gb

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

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