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Prognostic value of LA volumes assessed by transthoracic 3D echocardiography: Comparison with 2D echocardiography


Wu, VC-C and Takeuchi, M and Kuwaki, H and Iwataki, M and Nagata, Y and Otani, K and Haruki, N and Yoshitani, H and Tamura, M and Abe, H and Negishi, K and Lin, F-C and Otsuji, Y, Prognostic value of LA volumes assessed by transthoracic 3D echocardiography: Comparison with 2D echocardiography, JACC: Cardiovascular Imaging, 6, (10) pp. 1025-1035. ISSN 1936-878X (2013) [Refereed Article]

Copyright Statement


DOI: doi:10.1016/j.jcmg.2013.08.002


Objectives: The hypothesis of this study was that minimal left atrial volume index (LAVImin) by 3-dimensional echocardiography (3DE) is the best predictor of future cardiovascular events.

Background: Although maximal left atrial volume index (LAVImax) by 2-dimensional echocardiography (2DE) is a robust index for predicting prognosis, the prognostic value of LAVImin and the superiority of measurements by 3DE over 2DE have not been determined in a large group of patients.

Methods: In protocol 1, we assessed age and sex dependency of LAVIs using 2DE and 3DE in 124 normal subjects and determined their cutoff values (mean + 2 SD). In protocol 2, 2-dimensional (2D) and 3-dimensional (3D) LAVImax/LAVImin were measured in 556 patients with high prevalence of cardiovascular disease. After excluding patients with atrial fibrillation, mitral valve disease, and age <18 years, 439 subjects were followed to record major adverse cardiovascular events (MACE). Patients were divided into 2 groups by the cutoff criteria of LAVI in each method.

Results: In protocol 1, there was no significant age and sex dependency for each 2D and 3D LAVI. In protocol 2, during a mean of 2.5 years of follow-up, MACE developed in 88 patients, including 32 cardiac deaths. Kaplan-Meier survival analyses showed that all 4 LAVI cutoff criteria had significant predictive power of MACE. After variables were adjusted for clinical variables and left ventricular ejection fraction, all 4 methods were still independently and significantly associated with MACE, but 3D-derived LAVImin had the highest risk ratio. 3D LAVImin also had an incremental prognostic value over 3D LAVImax.

Conclusions: LAVIs by both 2DE and 3DE are powerful predictors of future cardiac events. 3D LAVImin tended to have a stronger and additive prognostic value than 3D LAVImax.

Item Details

Item Type:Refereed Article
Keywords:3D Echo, LA volume, prognosis
Research Division:Biomedical and Clinical Sciences
Research Group:Cardiovascular medicine and haematology
Research Field:Cardiology (incl. cardiovascular diseases)
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Negishi, K (Dr Kazuaki Negishi)
ID Code:87400
Year Published:2013
Web of Science® Times Cited:75
Deposited By:Menzies Institute for Medical Research
Deposited On:2013-11-14
Last Modified:2017-11-03

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