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Role of epithelial mesenchymal transition (EMT) in chronic obstructive pulmonary disease (COPD)

journal contribution
posted on 2023-05-21, 23:39 authored by Sukhwinder SohalSukhwinder Sohal, Eugene WaltersEugene Walters
Small airway fibrosis is the main contributor to physiological airway dysfunction in COPD. One potential mechanism contributing to small airway fibrosis is epithelial mesenchymal transition (EMT). When associated with angiogenesis (so called EMT-Type-3) it may well also be the link with the development of cancer, which is closely associated with COPD and predominantly in large airways. In a recent study published in Respiratory Research, Qin Wang and colleagues investigated the role of urokinase plasminogen activator receptor (uPAR) in EMT in small airway epithelium of COPD patients. However, there are some issues with the paper which we wish to comment on. © 2013 Sohal and Walters; licensee BioMed Central Ltd.

History

Publication title

Respiratory Research

Volume

14

Pagination

120

ISSN

1465-9921

Department/School

Tasmanian School of Medicine

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

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