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Role of epithelial mesenchymal transition (EMT) in chronic obstructive pulmonary disease (COPD)

Citation

Sohal, SS and Walters, EH, Role of epithelial mesenchymal transition (EMT) in chronic obstructive pulmonary disease (COPD), Respiratory Research, 14 pp. 120. ISSN 1465-9921 (2013) [Letter or Note in Journal]

DOI: doi:10.1186/1465-9921-14-120

Abstract

Small airway fibrosis is the main contributor to physiological airway dysfunction in COPD. One potential mechanism contributing to small airway fibrosis is epithelial mesenchymal transition (EMT). When associated with angiogenesis (so called EMT-Type-3) it may well also be the link with the development of cancer, which is closely associated with COPD and predominantly in large airways. In a recent study published in Respiratory Research, Qin Wang and colleagues investigated the role of urokinase plasminogen activator receptor (uPAR) in EMT in small airway epithelium of COPD patients. However, there are some issues with the paper which we wish to comment on. © 2013 Sohal and Walters; licensee BioMed Central Ltd.

Item Details

Item Type:Letter or Note in Journal
Research Division:Medical and Health Sciences
Research Group:Cardiorespiratory Medicine and Haematology
Research Field:Respiratory Diseases
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Respiratory System and Diseases (incl. Asthma)
Author:Sohal, SS (Dr Sukhwinder Sohal)
Author:Walters, EH (Professor Haydn Walters)
ID Code:87258
Year Published:2013
Web of Science® Times Cited:20
Deposited By:Medicine (Discipline)
Deposited On:2013-11-12
Last Modified:2013-11-12
Downloads:0

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