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Determinants of achieving early blood pressure control with monotherapy in a primary care setting


Stewart, S and Carrington, MJ and Swemmer, CH and Kurstjens, NP and Brown, A and Burrell, LM and Nelson, M and Stocks, NP and Jennings, GL, On behalf of the VIPER-BP Study Investigators, Determinants of achieving early blood pressure control with monotherapy in a primary care setting, Journal of Clinical Hypertension, 15, (9) pp. 674-680. ISSN 1524-6175 (2013) [Refereed Article]

Copyright Statement

Copyright 2013 Wiley Periodicals, Inc.

DOI: doi:10.1111/jch.12164


This study sought to identify the determinants of early blood pressure (BP) control associated with monotherapy in hypertensive individuals being managed in the primary care setting. The Valsartan Intensified Primary Care Reduction of Blood Pressure (VIPER-BP) study, was a multicenter, randomized controlled trial of an intensive approach to BP management. During a standardized run-in, 2185 participants commenced monotherapy (valsartan 80 mg/d) for 14 to 28 days. A total of 1978 participants aged 59±12 years (60% men) completed the run-in phase. Of these, 15.1%, 43.5%, and 41.4% participants had an initial BP target of ≤125/75, 130/80, and 140/90 mm Hg, respectively. A total of 416 of 2185 participants (19.0%) subsequently achieved their individual BP target during run-in with a mean BP change of -22.6±12.1/-12.9±8.2 mm Hg vs -4.2±16.2/-3.0±9.6 mm Hg for the rest (P < .001). These early responders were more likely to be women (adjusted odds ratio, 1.41; 95% confidence interval, 1.10-1.80), had lower BP at baseline, were less likely to have been treated previously (or for less time), and had a less stringent BP target. An initial period of monotherapy achieved BP control in a high proportion of hypertensive individuals with key groups (including women and de novo cases) more likely to show an early BP response. © 2013 Wiley Periodicals, Inc.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Cardiovascular medicine and haematology
Research Field:Cardiology (incl. cardiovascular diseases)
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Nelson, M (Professor Mark Nelson)
ID Code:87109
Year Published:2013
Web of Science® Times Cited:2
Deposited By:Menzies Institute for Medical Research
Deposited On:2013-11-07
Last Modified:2017-11-06

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